Camacho M Catalina, Deshpande Elina, Perino Michael T
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Neuropsychopharmacology. 2025 Sep 4. doi: 10.1038/s41386-025-02224-x.
Humans are intensely social creatures. It is therefore not surprising that many psychiatric disorder criteria include social dysfunctions; however, overlapping presentations and diverse, complex etiologies make treating social dysfunctions difficult. Here, we introduce the Cognitive Affective Social Processing and Emotion Regulation (CASPER) model. CASPER integrates research from social psychology, cognitive neuroscience, and developmental science to describe how real-world social processing unfolds and is associated with differing psychiatric social cognitive neurophenotypes. Briefly, social processing can be broken down into the following cognitive steps: identifying relevant social cues, attending to related cues, interpreting cues, and adjusting behavior appropriately. Each of these steps is influenced by the individual's affect and goals in the moment, which in turn influence which social concept or schema is activated for that interaction. Concepts are formed across development as we learn social skills and gain life experience. This model therefore links early experiences to social dysfunction "in the moment". The goal of this model is to provide a testable scientific framework for psychiatric research into social dysfunctions, as well as provide a model that generates new treatment targets for improving interventions and reinterpreting differences based on the extant research.
人类是高度社会化的生物。因此,许多精神疾病的标准中包含社会功能障碍也就不足为奇了;然而,症状的重叠以及病因的多样和复杂使得治疗社会功能障碍变得困难。在此,我们介绍认知情感社会加工与情绪调节(CASPER)模型。CASPER整合了社会心理学、认知神经科学和发展科学的研究成果,以描述现实世界中的社会加工是如何展开的,以及如何与不同的精神疾病社会认知神经表型相关联。简而言之,社会加工可以分解为以下认知步骤:识别相关社会线索、关注相关线索、解读线索以及适当地调整行为。这些步骤中的每一步都受到个体当下的情感和目标的影响,而这反过来又会影响在该互动中激活哪种社会概念或图式。随着我们学习社会技能并积累生活经验,概念在整个发展过程中逐渐形成。因此,该模型将早期经历与当下的社会功能障碍联系起来。此模型的目标是为精神疾病社会功能障碍的研究提供一个可检验的科学框架,同时提供一个模型,基于现有研究生成新的治疗靶点,以改进干预措施并重新解释差异。