Kerrison Clarence, Burgess Nicholas G
Department of Gastroenterology and Hepatology, Westmead Hospital, Sydney, NSW, 2145, Australia.
Westmead Clinical School of Medicine, The University of Sydney, Sydney, Australia.
Indian J Gastroenterol. 2025 Sep 4. doi: 10.1007/s12664-025-01838-9.
Endoscopic resection of pre-malignant polyps remains a cornerstone of colorectal cancer prevention. This review provides an evidence-based analysis of the current approaches to endoscopic colorectal polyp management. Cold snare resection is recommended for small and diminutive polyps. Sessile serrated lesions are safely and efficiently removed using cold snare with or without sub-mucosal lift. For large non-pedunculated colorectal polyps (LNPCPs), snare tip soft coagulation of the resection margins reduces recurrence, post-resection clip closure of proximal colon lesions prevents post-endoscopic mucosal resection (EMR) bleeding and early recognition of deep mural injury (DMI) using the Sydney DMI Classification guides intervention and prevents delayed perforation. Cold-forceps avulsion with adjuvant snare tip soft coagulation (CAST) is an effective tool for managing residual or recurrent adenoma. Endoscopic sub-mucosal dissection (ESD) is recommended for selected high-risk LNPCPs based on location and endoscopic optical assessment. This comprehensive review synthesises these points based on current evidence and provides practical guidance for endoscopists, aimed at improving resection of colorectal polyps to enhance patient outcomes and safety.
内镜下切除癌前息肉仍是预防结直肠癌的基石。本综述对当前内镜下结直肠息肉处理方法进行了循证分析。对于小息肉和微小息肉,推荐使用冷圈套器切除术。对于无蒂锯齿状病变,无论是否进行黏膜下抬举,使用冷圈套器均可安全有效地切除。对于大的无蒂结直肠息肉(LNPCP),圈套器尖端对切除边缘进行软凝可降低复发率,对近端结肠病变进行切除后夹子闭合可预防内镜下黏膜切除术(EMR)后出血,使用悉尼深部壁层损伤(DMI)分类早期识别深部壁层损伤可指导干预并预防延迟穿孔。冷活检钳切除术联合辅助圈套器尖端软凝(CAST)是处理残留或复发性腺瘤的有效工具。对于根据位置和内镜光学评估选定的高危LNPCP,推荐进行内镜黏膜下剥离术(ESD)。本综述基于当前证据综合了这些要点,并为内镜医师提供了实用指导,旨在改善结直肠息肉切除术,提高患者的治疗效果和安全性。