Bruckner Anna L, Murrell Dédée, Lee Lara Wine, Sprecher Eli, Kiritsi Dimitra, Maher Laura, Löwe Sandra, Donovan Maryanne, Kern Johannes S
Department of Dermatology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Department of Dermatology, St. George Hospital, University of new South Wales, Sydney, New South Wales, Australia.
J Dermatol. 2025 Sep;52(9):1447-1451. doi: 10.1111/1346-8138.17884. Epub 2025 Aug 1.
Epidermolysis bullosa (EB) is a severe genetic disorder marked by skin fragility and blistering from minimal trauma. Management relies on frequent and painful dressing changes. The EASE study (NCT03068780), the largest to date in EB, previously demonstrated accelerated wound healing and reduced wound burden for Oleogel-S10 (birch triterpenes) versus control gel. This post hoc analysis focused on dressing change frequency and related time and cost savings among patients with daily dressing changes at baseline (Oleogel-S10 n = 47, control gel n = 53). By Day 90, 35.6% of Oleogel-S10 patients required fewer daily changes versus 10.6% in the control group (p = 0.005). Weekly dressing changes reduced by 1.36 ± 0.24 with Oleogel-S10 compared to 0.41 ± 0.23 for control (difference -0.95 ± 0.33; p = 0.005). This translated to almost three fewer dressing changes every 2 weeks for Oleogel-S10 versus nearly one change for the control gel. The estimated time saved per week was 10.7 h with Oleogel-S10 (6.4 h patient, 4.3 h caregiver) versus 4.0 h with control (2.4 h patient, 1.6 h caregiver). Estimated dressing costs reduced by 59%, from $63.4 k to $25.9 k per patient over 27 months. Oleogel-S10 significantly reduced dressing frequency and time burden, with potential to ease the intensive demands of EB wound care.
大疱性表皮松解症（EB）是一种严重的遗传性疾病，其特征是皮肤脆弱，轻微创伤即可导致水疱形成。治疗依赖于频繁且痛苦的换药。EASE研究（NCT03068780）是迄今为止关于EB的最大规模研究，此前已证明与对照凝胶相比，Oleogel-S10（桦木三萜）可加速伤口愈合并减轻伤口负担。这项事后分析聚焦于基线时每天换药的患者（Oleogel-S10组n = 47，对照凝胶组n = 53）的换药频率以及相关的时间和成本节省情况。到第90天时，35.6%使用Oleogel-S10的患者每日换药次数减少，而对照组为10.6%（p = 0.005）。与对照组每周换药次数减少0.41±0.23次相比，使用Oleogel-S10后每周换药次数减少1.36±0.24次（差异为-0.95±0.33；p = 0.005）。这意味着Oleogel-S10每2周的换药次数比对照凝胶几乎少三次。使用Oleogel-S10每周估计节省的时间为10.7小时（患者6.4小时，护理人员4.3小时），而对照凝胶为4.0小时（患者2.4小时，护理人员1.6小时）。估计换药成本降低了59%，每位患者在27个月内从63.4千美元降至25.9千美元。Oleogel-S10显著降低了换药频率和时间负担，有可能缓解EB伤口护理的高强度需求。
