McManus Sheighlah, Khare Priyanka, Bertilaccio Maria Teresa S
Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
The University of Texas MD Anderson Cancer Center, UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, United States.
Front Immunol. 2025 Aug 20;16:1609754. doi: 10.3389/fimmu.2025.1609754. eCollection 2025.
This review explores neutrophils' roles in chronic lymphocytic leukemia (CLL), highlighting their functions within the immune system. While neutrophils are known for fighting infections, their altered behavior in CLL significantly impacts disease progression. This review notes the reduced phagocytic abilities of neutrophils and the increased formation of neutrophil extracellular traps (NETs) in patients with CLL. It also examines the effects of CLL treatments, including chemotherapy, immunotherapy and targeted therapies, on neutrophils' count and function, stressing the need for improved strategies to manage therapy-induced immune dysfunction. This review also provides detailed information about the interactions between neutrophils and other immune elements in CLL microenvironment, providing insights for developing therapeutic approaches that can restore immune function and improve patients' quality of life.
本综述探讨了中性粒细胞在慢性淋巴细胞白血病（CLL）中的作用，重点介绍了它们在免疫系统中的功能。虽然中性粒细胞以对抗感染而闻名，但其在CLL中的行为改变显著影响疾病进展。本综述指出，CLL患者中性粒细胞的吞噬能力降低，中性粒细胞胞外诱捕网（NETs）的形成增加。它还研究了CLL治疗（包括化疗、免疫疗法和靶向疗法）对中性粒细胞数量和功能的影响，强调需要改进策略来管理治疗引起的免疫功能障碍。本综述还提供了有关CLL微环境中中性粒细胞与其他免疫成分之间相互作用的详细信息，为开发能够恢复免疫功能并改善患者生活质量的治疗方法提供了见解。
