Coraim F, Wolner E
Acta Med Austriaca. 1985;12(3-4):105-11.
In 326 cardiac surgical patients equal results could be achieved when CAVH was performed either before, during or after extracorporal circulation. Following CAVH improvement of haemodynamic parameters as well as pulmonary function could clearly be shown. This improvement was mainly due to the clearance of all cardiopulmonary toxic substances weighing less than 50.000 daltons. Since the negative inotropic effect of MDF (MW 800 to 1000 daltons) is known to be an important reason for "low cardiac output syndrome" elimination of MDF is one advantageous benefit of CAVH apart from dehydration. By means of bioassays our experiences demonstrated the capability of CAVH to clear MDF to a remarkable degree.
在326例心脏外科手术患者中,无论在体外循环前、体外循环期间还是体外循环后进行连续性动静脉血液滤过(CAVH),均可取得相同的效果。CAVH后,血流动力学参数以及肺功能的改善均得到明显证实。这种改善主要归因于清除了所有分子量小于50,000道尔顿的心肺毒性物质。由于已知心肌抑制因子(MDF,分子量800至1000道尔顿)的负性肌力作用是“低心排血量综合征”的一个重要原因,因此除脱水外,清除MDF是CAVH的一个有利作用。通过生物测定,我们的经验表明CAVH清除MDF的能力非常显著。