Partington Lindsey C, Yuan Haiying, Demuyakor Maku E, Adu-Afarwuah Seth, Guyer Amanda E, Dewey Kathryn G, Kumordzie Sika M, Oaks Brietta M, Arnold Charles D, Prado Elizabeth L, Hastings Paul D
Institute for Global Nutrition, University of California, Davis, Davis, CA, United States.
Center for Mind & Brain, University of California, Davis, Davis, CA, United States.
Front Nutr. 2025 Aug 20;12:1571677. doi: 10.3389/fnut.2025.1571677. eCollection 2025.
This study examines how an early-life small-quantity lipid-based nutrient supplement (LNS) interacts with the home environment to influence Ghanaian children's social-emotional functioning at preschool age.
In a randomized controlled trial, 1,320 Ghanaian women received either daily LNS, multiple micronutrients (MMN) or iron and folic acid (IFA) during pregnancy through 6 months postpartum. Infants in the LNS group received the daily supplement from 6 to 18 months. The IFA and MMN groups were combined to be the control group. At 4-6 years ( = 966), we assessed children's home environments (caregiver responsivity, negative behavior acceptance, physical environment, learning materials, academic stimulation) and their social-emotional strengths and difficulties.
Both LNS and higher quality home environments-particularly caregiver responsivity and negative behavior acceptance-predicted children having fewer social-emotional difficulties. LNS supplementation moderated relations between the home environment and children's hyperactivity/inattention and total difficulties. Living in a safer physical environment was related to fewer hyperactivity/inattention problems and total difficulties only for children who received LNS. Less academic stimulation was related to more hyperactivity/inattention only for children in the control group.
Early-life LNS supplementation and supportive home environments reduce social-emotional difficulties in Ghanaian children. Nutritional interventions are most effective in the context of safe, stimulating households, demonstrating that integrated interventions support children's wellbeing in low- and middle-income countries.
clinicaltrials.gov; identifier: NCT00970866.
本研究探讨了早期小剂量脂质基营养补充剂（LNS）如何与家庭环境相互作用，以影响加纳学龄前儿童的社会情感功能。
在一项随机对照试验中，1320名加纳妇女在孕期至产后6个月期间每天接受LNS、多种微量营养素（MMN）或铁和叶酸（IFA）。LNS组的婴儿在6至18个月期间每天接受补充剂。IFA组和MMN组合并为对照组。在4至6岁时（n = 966），我们评估了儿童的家庭环境（照顾者反应性、对负面行为的接受度、物理环境、学习材料、学业刺激）以及他们的社会情感优势和困难。
LNS和更高质量的家庭环境——特别是照顾者反应性和对负面行为的接受度——都预示着儿童的社会情感困难较少。补充LNS调节了家庭环境与儿童多动/注意力不集中及总体困难之间的关系。只有接受LNS的儿童，生活在更安全的物理环境中与较少的多动/注意力不集中问题及总体困难相关。只有对照组的儿童，较少的学业刺激与更多的多动/注意力不集中相关。
早期补充LNS和支持性的家庭环境可减少加纳儿童的社会情感困难。营养干预在安全、有刺激的家庭环境中最为有效，这表明综合干预有助于低收入和中等收入国家儿童的福祉。
clinicaltrials.gov；标识符：NCT00970866。
