Hamzah Hamzah, Suryanti Suryanti, Ahmed Idris Adewale, Semedi Bambang Pujo, Machin Abdullah, Hernowo Aditya Tri
Universitas Batam, Batam, Riau Islands, Indonesia.
Lincoln University College, Petaling Jaya, Selangor, Malaysia.
F1000Res. 2025 Aug 19;14:406. doi: 10.12688/f1000research.162742.3. eCollection 2025.
Stroke remains a leading cause of mortality and long-term disability worldwide, necessitating innovative therapeutic strategies. The advent of nanotechnology, particularly oxygen-delivering nanobubbles (ODNBs), has introduced a promising avenue for enhancing stroke therapy. ODNBs have demonstrated the ability to improve oxygen delivery, enhance therapeutic efficacy, and provide diagnostic advantages through imaging contrast enhancement. However, challenges such as toxicity, off-target effects, and regulatory hurdles must be addressed before clinical translation. This review synthesizes the latest findings on ODNBs in stroke therapy, highlights their key benefits and challenges, and explores future applications, including gene therapy and brain tissue regeneration. By addressing these aspects, this review aims to provide a comprehensive understanding of the potential of ODNBs in revolutionizing stroke treatment.
中风仍然是全球死亡率和长期残疾的主要原因，因此需要创新的治疗策略。纳米技术的出现，特别是携氧纳米气泡（ODNBs），为增强中风治疗提供了一条有前景的途径。ODNBs已证明能够改善氧气输送、提高治疗效果，并通过增强成像对比度提供诊断优势。然而，在临床转化之前，必须解决毒性、脱靶效应和监管障碍等挑战。本综述综合了关于ODNBs在中风治疗方面的最新研究结果，强调了它们的主要益处和挑战，并探索了包括基因治疗和脑组织再生在内的未来应用。通过阐述这些方面，本综述旨在全面了解ODNBs在变革中风治疗方面的潜力。
