Wang Jing, Zhang Heli, Zhang Xiaotian, Wang Jingpin, Chen Hongbo, Li Baohua
Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital, Beijing, China.
Department of Rehabilitation Medicine, Peking University Third Hospital, Beijing, China.
Front Public Health. 2025 Aug 20;13:1554793. doi: 10.3389/fpubh.2025.1554793. eCollection 2025.
Metabolic dysfunction-associated fatty liver disease (MAFLD) refer to fatty liver disease related to systemic metabolic dysregulation, which is closely related to unhealthy lifestyles such as staying up late and eating irregularly. MAFLD has become most prevalent chronic liver disease and become a high incidence disease among nurses. Health and good condition of nurses are the basis to ensure the safety and quality of life of patients. Little is known about the risk factors of MAFLD in nurses.
We conducted an ambispective cohort study of the National Nurses' Health Study from 2018 to 2022 in a tertiary hospital in China. The data were collected by questionnaires and physical examination records. Analysis was done using SPSS 26.0. Risk factors for MAFLD were estimated by multivariable Cox proportional hazard regression using forward stepwise selection.
A total of 777 nurses were included in this study. The incidence of MAFLD in nurses exceeds the global average. Age at diagnosis ( = 0.011), BMI ( = 0.000), FBG ( = 0.048), TG ( = 0.009), uric acid ( = 0.011), female ( = 0.012), like eating oily food ( = 0.049) and spicy food ( = 0.028), and frequency of outgoing-food ( = 0.042) were risk factors for MAFLD.
The incidence of MAFLD in nurses was higher than the global average and has become an occupational health concern. Age, BMI, female gender, fasting blood glucose (FBG), triglycerides (TG), uric acid, oily foods, spicy foods, and the frequency of eating out were risk factors for MAFLD occurrence. In the future, the focus should be on risk factors for MAFLD in nurses and developing intervention programs to improve nurse health and well being.
代谢功能障碍相关脂肪性肝病（MAFLD）是指与全身代谢失调相关的脂肪性肝病，与熬夜、饮食不规律等不健康生活方式密切相关。MAFLD已成为最常见的慢性肝病，在护士中成为高发疾病。护士的健康状况是确保患者安全和生活质量的基础。目前对护士中MAFLD的危险因素知之甚少。
我们于2018年至2022年在中国一家三级医院对全国护士健康研究进行了一项双向队列研究。数据通过问卷调查和体格检查记录收集。使用SPSS 26.0进行分析。通过多变量Cox比例风险回归采用向前逐步选择法估计MAFLD的危险因素。
本研究共纳入777名护士。护士中MAFLD的发病率超过全球平均水平。诊断时年龄（=0.011）、体重指数（BMI）（=0.000）、空腹血糖（FBG）（=0.048）、甘油三酯（TG）（=0.009）、尿酸（=0.011）、女性（=0.012）、喜欢吃油腻食物（=0.049）和辛辣食物（=0.028）以及外出就餐频率（=0.042）是MAFLD的危险因素。
护士中MAFLD的发病率高于全球平均水平，已成为职业健康问题。年龄、BMI、女性性别、空腹血糖（FBG）、甘油三酯（TG）、尿酸、油腻食物、辛辣食物以及外出就餐频率是MAFLD发生的危险因素。未来，应关注护士中MAFLD的危险因素，并制定干预计划以改善护士的健康和福祉。
