Department of Gastroenterology, Zhejiang Provincial Clinical Research Center for Digestive Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine. No, 79 Qingchun Road, Hangzhou, 310003, China.
Department of Gastroenterology, Ningbo First Hospital, Ningbo, China.
BMC Public Health. 2023 Jul 3;23(1):1282. doi: 10.1186/s12889-023-16204-7.
This study aimed to investigate the association between night shift work and the risk of nonalcoholic fatty liver disease (NAFLD).
We conducted a prospective analysis of 281,280 UK Biobank participants. Cox proportional hazards models were used to estimate the association of night shift work with incident NAFLD. Polygenic risk score analyses were performed to assess whether a genetic predisposition to NAFLD modified the association.
During a median follow-up of 12.1 years (3,373,964 person-years), 2,555 incident NAFLD cases were identified. Compared with workers who never/rarely worked night shifts, those who worked some night shifts or usual/permanent night shifts were 1.12 (95% CI: 0.96-1.31) and 1.27 (95% CI: 1.08-1.48) times more likely to develop NAFLD, respectively. Among the 75,059 participants who had reports on lifetime experience of night shift work, those with a longer duration, a higher frequency, more consecutive night shifts and a longer length per shift all showed higher risks of incident NAFLD. Further analyses showed that the association between night shift work and incident NAFLD was not modified by a genetic predisposition to NAFLD.
Night shift work was associated with increased risks of incident NAFLD.
本研究旨在探讨夜班工作与非酒精性脂肪性肝病（NAFLD）风险之间的关联。
我们对 281280 名英国生物库参与者进行了前瞻性分析。使用 Cox 比例风险模型估计夜班工作与新发 NAFLD 的相关性。进行多基因风险评分分析，以评估 NAFLD 的遗传易感性是否改变了这种相关性。
在中位随访 12.1 年（3373964 人年）期间，共发现 2555 例新发 NAFLD 病例。与从不/很少上夜班的工人相比，偶尔上夜班或经常/永久上夜班的工人发生 NAFLD 的风险分别增加 1.12 倍（95%CI：0.96-1.31）和 1.27 倍（95%CI：1.08-1.48）。在 75059 名有夜班工作经历报告的参与者中，夜班工作持续时间较长、频率较高、连续夜班较多、每次夜班时间较长的参与者，新发 NAFLD 的风险均较高。进一步分析表明，夜班工作与新发 NAFLD 之间的关联不受 NAFLD 遗传易感性的影响。
夜班工作与新发 NAFLD 的风险增加相关。
