Huo Rongxiu, Wei Chengcheng, Yang Yanting, Yang Yang, Huo Xiaocong, Wang Bangqin, Meng Danli, Huang Yijia, Huang Rongjun, Lin Jinying, Huang Xinxiang
Department of Rheumatology and Immunology, Guangxi Academy of Medical Sciences, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Autonomous Region 530016, P.R. China.
Mol Med Rep. 2025 Nov;32(5). doi: 10.3892/mmr.2025.13670. Epub 2025 Sep 5.
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized primarily by arterial and/or venous thrombosis, obstetric complications and persistent positivity for antiphospholipid antibodies (aPLs). It has been proposed that the pathogenesis of APS is closely associated with vascular endothelial cell activation, complement activation and platelet activation. Notably, APS may be key to understanding the relationship between innate immune cells, and thrombosis and obstetric complications. Monocytes are activated by aPLs, adopting a pro‑inflammatory and pro‑coagulant phenotype, and producing inflammatory cytokines; however, the exact mechanisms of action of monocytes in APS remain unclear. Monocytes may act as an intermediary, triggering immune dysregulation, closely linking them to thrombosis and obstetric complications. Therefore, a better understanding of the potential pathogenic role of monocytes in APS is required, which could assist clinicians in gaining deeper insights into the pathogenesis of APS and identifying new therapeutic targets. This may provide new options for the management of APS. Therefore, the present study aimed to review monocytes and their role in APS.
抗磷脂综合征（APS）是一种自身免疫性疾病，主要特征为动脉和/或静脉血栓形成、产科并发症以及抗磷脂抗体（aPLs）持续呈阳性。有人提出，APS的发病机制与血管内皮细胞活化、补体活化和血小板活化密切相关。值得注意的是，APS可能是理解天然免疫细胞与血栓形成及产科并发症之间关系的关键。单核细胞被aPLs激活，呈现促炎和促凝表型，并产生炎性细胞因子；然而，单核细胞在APS中的具体作用机制仍不清楚。单核细胞可能作为一种中介，引发免疫失调，将它们与血栓形成和产科并发症紧密联系起来。因此，需要更好地了解单核细胞在APS中的潜在致病作用，这有助于临床医生更深入地了解APS的发病机制并确定新的治疗靶点。这可能为APS的管理提供新的选择。因此，本研究旨在综述单核细胞及其在APS中的作用。
