Bafunyembaka Gabriel, Nacher Mathieu, Maniassom Chimène, Birindwa Archippe, Elenga Narcisse
Department of Pediatrics, Franck Joly Hospital, Western French Guiana, Avenue Paul Castaing Saint-Laurent du Maroni GF 97320, Guyane Française, French Guiana, France.
Clinical Investigation Center, Epidemiology/Public Health, Inserm 1424, Cayenne Hospital, Avenue Alexis Blaise 97300 Cayenne, French Guiana, France.
Indian J Pediatr. 2025 Sep 5. doi: 10.1007/s12098-025-05749-7.
To evaluate the impact of asthma on hospitalizations for acute vaso-occlusive pain episodes in children with sickle cell disease (SCD).
A multicenter nested case-control study was conducted over a period from January 1, 2012, to December 31, 2022.
The mean age of the study population was 8.41 ± 5.04 y, with an equal distribution of males and females. Among the 600 children with SCD included in the study, 35 were diagnosed with asthma, yielding a prevalence of 5.8%. Children with both SCD and asthma had a median of 6 hospitalizations (Range: 2-20), compared to 2 (Range: 1-4) in those without asthma (p < 0.001). In 90% of these cases, asthma exacerbation coincided with a sickle cell crisis. Besides vaso-occlusive episodes, other leading causes of hospitalization included pulmonary infections and acute chest syndrome. The incidence of acute chest syndrome was found to be 18 times higher in children with both asthma and sickle cell disease. Furthermore, children with both conditions were 3.99 times more likely to experience a vaso-occlusive crisis requiring hospitalization than those without asthma.
Children with sickle cell disease and asthma co-morbidity experience a significantly higher number of vaso-occlusive crises requiring hospitalization.
评估哮喘对镰状细胞病（SCD）患儿急性血管闭塞性疼痛发作住院情况的影响。
于2012年1月1日至2022年12月31日期间开展了一项多中心巢式病例对照研究。
研究人群的平均年龄为8.41±5.04岁，男女分布均衡。在纳入研究的600例SCD患儿中，35例被诊断为哮喘，患病率为5.8%。患有SCD和哮喘的患儿住院中位数为6次（范围：2 - 20次），而无哮喘患儿的住院中位数为2次（范围：1 - 4次）（p < 0.001）。在90%的这些病例中，哮喘加重与镰状细胞危象同时发生。除血管闭塞性发作外，其他主要住院原因包括肺部感染和急性胸综合征。发现同时患有哮喘和镰状细胞病的患儿急性胸综合征的发生率高出18倍。此外，同时患有这两种疾病的患儿发生需要住院治疗的血管闭塞性危象的可能性是无哮喘患儿的3.99倍。
患有镰状细胞病和哮喘合并症的患儿因血管闭塞性危象而需要住院治疗的次数显著更多。
