Murakami S, Igarashi T, Takahara M, Yamanishi T, Otani K, Yoshizawa H, Hashizume S
Hinyokika Kiyo. 1985 Nov;31(11):1965-9.
Sixty-one male urethritis cases, 28 gonococcal urethritis and 33 nongonococcal urethritis (NGU), were out-patients at the Department of Urology, Asahi General Hospital, during the 4 months, Oct. 1, 1984-Jan. 31, 1985. Thirteen of the 33 NGU patients (39.4%) were infected with C. trachomatis (CT). The efficacy of Doxycycline and the route of infection was studied in the cases of CT-positive CT-negative-NGU. CT infection from prostitutes was not so frequent as in the other pathogen infection of NGU. The efficacy of Doxycycline (100 mg b.i.d. for 2 weeks) against CT infection was excellent in the disappearance of subjective complaints and that of white blood cells in the urethral discharge in the CT positive-NGU group (13/13), in comparison with CT negative-NGU group (7/18). The efficacy of Doxycycline against CT was also confirmed from the follow-up study by the isolation of CT and by detection of CT antigen from urethral swabs using FITC conjugated monoclonal antibody against CT antigen.
1984年10月1日至1985年1月31日的4个月期间，61例男性尿道炎患者，其中28例为淋菌性尿道炎，33例为非淋菌性尿道炎（NGU），均为朝日综合医院泌尿外科门诊患者。33例NGU患者中有13例（39.4%）感染沙眼衣原体（CT）。对CT阳性和CT阴性的NGU病例研究了强力霉素的疗效及感染途径。CT感染来自妓女的情况不像NGU的其他病原体感染那样常见。与CT阴性的NGU组（7/18）相比，CT阳性的NGU组（13/13）中，强力霉素（100mg，每日2次，共2周）对CT感染在主观症状消失及尿道分泌物白细胞消失方面疗效极佳。通过CT分离及使用抗CT抗原的异硫氰酸荧光素结合单克隆抗体从尿道拭子检测CT抗原的随访研究也证实了强力霉素对CT的疗效。
