Den'o Zenebe Debena, Paulos Wondimagegn, Markos Desta, Oche Woldetsadik Oshine, Milkano Tamirat Mathewos
Maternal, Child and Nutrition Department, Merab Abaya District Health OfficeBribir, Ethiopia.
School of Public Health, College of Medicine and Health Science, Wolaita Sodo University, Wolaita Sodo, Ethiopia.
PLoS One. 2025 Sep 5;20(9):e0330760. doi: 10.1371/journal.pone.0330760. eCollection 2025.
Human papillomavirus (HPV) vaccination is a well-established global strategy for the prevention of cervical cancer. However, the uptake of the vaccine varies across regions and countries due to several factors. Although girls are at risk for cervical cancer, there are limited studies measuring vaccination uptake among female adolescents in the study area.
To assess human papilloma virus vaccination uptake and associated factors among adolescent girls, in Merab Abaya district, Gamo Zone, southern Ethiopia, 2024.
A community-based cross-sectional mixed-method study was conducted among 626 adolescent girls selected using a two-stage sampling technique in Merab Abaya District, Gamo Zone, from February 1 to March 30, 2024. For the qualitative component, participants were selected using a purposive sampling technique. Data were entered using EpiData version 4.62 and analyzed using SPSS version 26. Logistic regression was performed to examine the association between the dependent variable and associated factors. Variables with a p-value < 0.05 in the multivariate analysis were considered statistically significant. For qualitative data analysis, OpenCode 4.02 software was used to conduct thematic content analysis.
A total of 601 adolescent girls participated in this study, yielding a response rate of 96%. Of these, 324 (53.9%; 95% CI: 49.9-57.9%) had received the human papillomavirus vaccine. Vaccine uptake was significantly associated with: Good knowledge about the HPV vaccine (AOR = 3.4; 95% CI: 2.14-5.38), A positive attitude toward the HPV vaccine (AOR = 1.7; 95% CI: 1.02-2.78), Recommendation from health workers to get vaccinated (AOR = 3.8; 95% CI: 2.25-6.50), Family support for vaccination (AOR = 7.1; 95% CI: 3.97-12.60). Qualitative findings identified mistrust of the HPV vaccine, irregular vaccine provision, and lack of information provision as major barriers to uptake.
In this study, nearly fifty-four percent of adolescent girls had received the HPV vaccine. The overall uptake of the HPV vaccine among adolescent girls remains low. Good knowledge about the HPV vaccine, a positive attitude toward it, recommendations from health workers, and family support were significantly associated with vaccine uptake. Therefore, health facilities and schools should strengthen community-based health education aimed at promoting behavioral change regarding the HPV vaccine and focus on creating various training opportunities for health workers and teachers.
人乳头瘤病毒（HPV）疫苗接种是预防宫颈癌的一项成熟的全球战略。然而，由于多种因素，该疫苗在不同地区和国家的接种率有所不同。尽管女孩面临宫颈癌风险，但在研究区域内，针对女性青少年疫苗接种情况的研究有限。
评估2024年埃塞俄比亚南部加莫地区梅拉布阿巴亚区青春期女孩的人乳头瘤病毒疫苗接种情况及相关因素。
2024年2月1日至3月30日，在加莫地区梅拉布阿巴亚区采用两阶段抽样技术选取626名青春期女孩，开展了一项基于社区的横断面混合方法研究。对于定性部分，采用目的抽样技术选取参与者。数据使用EpiData 4.62版本录入，并使用SPSS 26版本进行分析。进行逻辑回归以检验因变量与相关因素之间的关联。多变量分析中p值<0.05的变量被认为具有统计学意义。对于定性数据分析，使用OpenCode 4.02软件进行主题内容分析。
共有601名青春期女孩参与本研究，应答率为96%。其中，324名（53.9%；95%可信区间：49.9 - 57.9%）接种了人乳头瘤病毒疫苗。疫苗接种与以下因素显著相关：对HPV疫苗的充分了解（调整后比值比[AOR]=3.4；95%可信区间：2.14 - 5.38）、对HPV疫苗的积极态度（AOR = 1.7；95%可信区间：1.02 - 2.78）、医护人员的接种建议（AOR = 3.8；95%可信区间：2.25 - 6.5）、家庭对疫苗接种的支持（AOR = 7.1；95%可信区间：3.97 - 12.6）。定性研究结果表明，对HPV疫苗的不信任、疫苗供应不规律以及信息提供不足是疫苗接种的主要障碍。
在本研究中，近54%的青春期女孩接种了HPV疫苗。青春期女孩中HPV疫苗的总体接种率仍然较低。对HPV疫苗的充分了解、积极态度、医护人员的建议以及家庭支持与疫苗接种显著相关。因此，医疗机构和学校应加强基于社区的健康教育，以促进在HPV疫苗接种方面的行为改变，并着重为医护人员和教师创造各种培训机会。
