Zhou F Y, Zhao Liping, Deng Yuqian, Guo Chunbo, Liu Lan
Xiangya School of Nursing, Central South University, Changsha, Hunan, China.
Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
BMJ Open. 2025 Sep 5;15(9):e097048. doi: 10.1136/bmjopen-2024-097048.
Frailty is a global health issue, particularly among older adults, and is strongly associated with adverse health outcomes. The intermediate stage of pre-frailty, which represents a transition from robust health to frailty, has garnered growing concern due to its potential reversibility. This systematic review and meta-analysis will aim to identify predictors associated with the progression from pre-frailty to frailty in older adults.
A comprehensive literature search will be conducted in PubMed, Web of Science, Embase, Cochrane Library, CINAHL, PsycINFO, CNKI, Wanfang Database, China Science and Technology Journal Database, and China Biomedical Literature Database from inception to the most recent search date. Eligible studies will report predictors of frailty progression among older adults with pre-frailty at baseline. Two reviewers will independently screen the studies, extract relevant data and assess methodological quality using the Newcastle Ottawa Scale. Meta-analysis and meta-regression will be performed to estimate pooled effect sizes and explore potential predictors. Subgroup analyses will be conducted to investigate possible sources of heterogeneity.
Ethical approval will not be required, as this study will not involve primary data collection. The findings will be submitted for publication in a peer-reviewed scientific journal.
CRD42024594175.
衰弱是一个全球性的健康问题，在老年人中尤为突出，并且与不良健康结局密切相关。脆弱前期这一中间阶段代表着从健康状态向衰弱的转变，因其具有潜在的可逆性而受到越来越多的关注。本系统评价和荟萃分析旨在确定与老年人从脆弱前期进展到衰弱相关的预测因素。
将在PubMed、Web of Science、Embase、Cochrane图书馆、CINAHL、PsycINFO、中国知网、万方数据库、中国科技期刊数据库和中国生物医学文献数据库中进行全面的文献检索，检索时间从建库至最近的检索日期。符合条件的研究将报告基线时处于脆弱前期的老年人衰弱进展的预测因素。两名评价者将独立筛选研究、提取相关数据，并使用纽卡斯尔-渥太华量表评估方法学质量。将进行荟萃分析和荟萃回归以估计合并效应量并探索潜在的预测因素。将进行亚组分析以调查异质性的可能来源。
本研究无需伦理批准，因为该研究不涉及原始数据收集。研究结果将提交至同行评审的科学期刊发表。
PROSPERO注册号：CRD42024594175。
