Dehghani Mehdi, Nooralishahi Behrang, Rezaee Tazangi Fatemeh
Tehran Heart Center, Cardiovascular Diseases Research Institute, Anesthesiology, Critical Care and Pain Research Center, Tehran University of medical science, Tehran, Iran.
Tehran Heart Center, Cardiovascular Diseases Research Institute, Anesthesiology, Critical care, and Pain Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mol Pain. 2025 Sep 5;21:17448069251380033. doi: 10.1177/17448069251380033.
Pain stands as one of the main factors related to human disability and suffering, with different classifications (e.g., acute/chronic, somatic/visceral, and malignant/non-malignant). The management of this factor is of great importance during the lifespan; however, the current suggested medications have not yet reflected sufficient effectiveness with minimum side effects. Therefore, applying an ideal strategy against conditions accompanied by pain is urgent. A growing body of evidence has recently highlighted that alkaloids as bioactive compounds with analgesic capacity can be effective in these conditions. Regarding this matter, dehydrocorydaline, a bioactive alkaloid derived from the tubers of Rhizoma Corydalis, has shown promising results in pain management in diseases, including Chronic constriction injury, bone cancer, sleep deprivation, and inflammatory pain. Also, dehydrocorydaline has been shown to exert different biological and pharmacological benefits, like anti-tumor, anti-inflammatory, anti-microbial, anti-viral, anti-nociceptive, and cardioprotective. Hence, in this literature review, we aimed to explore the potential of this alkaloid agent in these conditions with a mechanistic insight.
疼痛是导致人类残疾和痛苦的主要因素之一，有不同的分类（如急性/慢性、躯体性/内脏性、恶性/非恶性）。在人的一生中，对这一因素的管理至关重要；然而，目前推荐的药物尚未充分体现出疗效显著且副作用最小的特点。因此，迫切需要针对伴有疼痛的病症应用理想的策略。最近，越来越多的证据表明，生物碱作为具有镇痛能力的生物活性化合物，在这些病症中可能有效。关于这一点，脱氢紫堇碱是一种从延胡索块茎中提取的生物活性生物碱，在包括慢性压迫性损伤、骨癌、睡眠剥夺和炎性疼痛等疾病的疼痛管理中已显示出有前景的结果。此外，脱氢紫堇碱已被证明具有不同的生物学和药理学益处，如抗肿瘤、抗炎、抗微生物、抗病毒、抗伤害感受和心脏保护作用。因此，在这篇文献综述中，我们旨在从机制角度探讨这种生物碱制剂在这些病症中的潜力。
