Jotereau F
Ann Biol Clin (Paris). 1985;43(5):767-72.
The haematogenous origin of osteoclasts has been demonstrated in recent years by the use of cellular markers in experiments in early bone grafts in bird embryos and the transfer of haematopoietic cells in the osteoporotic mammals. The nature of the mononuclear precursor(s) of the osteoclasts has not been determined. Studies currently underway demonstrate that relatively immature cells present in the bone marrow of adults and in various embryonic haematopoietic organs, as well as blood monocytes are capable of participating in osteoclastic differentiation in various animal models.
近年来，通过在鸟类胚胎早期骨移植实验中使用细胞标记物以及在骨质疏松的哺乳动物中进行造血细胞转移，已证实破骨细胞的血源性。破骨细胞单核前体的性质尚未确定。目前正在进行的研究表明，存在于成年动物骨髓和各种胚胎造血器官中的相对不成熟细胞以及血液单核细胞能够在各种动物模型中参与破骨细胞的分化。
