强力霉素预防用药方案：扩展机遇
DoxyPEP: Opportunities for Expansion.
作者信息
Wu En-Ling, Pagkas-Bather Jade, Hazra Aniruddha, Pho Mai T
机构信息
Department of Medicine, University of Chicago, Chicago, Illinois, USA.
出版信息
J Prim Care Community Health. 2025 Jan-Dec;16:21501319251370497. doi: 10.1177/21501319251370497. Epub 2025 Sep 6.
Abstract
Clinical trials show that doxycycline post-exposure prophylaxis (DoxyPEP) significantly reduces the risk of bacterial sexually transmitted infections (STIs), especially syphilis and chlamydia, in cisgender men who have sex with men and transgender women. Real-world data suggest DoxyPEP may be beneficial for other populations disproportionately affected by STIs. Given the ongoing STI epidemic we recommend discussing DoxyPEP with all eligible patients. We review clinical guidelines and practical considerations surrounding DoxyPEP, highlight areas for future research, and propose strategies for implementation.
摘要
临床试验表明，多西环素暴露后预防（DoxyPEP）可显著降低与男性发生性行为的顺性别男性和跨性别女性感染细菌性性传播感染（STIs）的风险，尤其是梅毒和衣原体感染。现实世界的数据表明，DoxyPEP可能对其他受性传播感染影响较大的人群有益。鉴于当前性传播感染的流行情况，我们建议与所有符合条件的患者讨论DoxyPEP。我们回顾了围绕DoxyPEP的临床指南和实际考虑因素，强调了未来研究的领域，并提出了实施策略。
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本文引用的文献
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Doxycycline Postexposure Prophylaxis for Bacterial STIs: Prescribing Patterns, Use, Short-term Outcomes Among 2083 Patients in a Los Angeles Federally Qualified Health Care Program, and Implications for Widespread Use.多西环素用于细菌性性传播感染的暴露后预防：洛杉矶联邦合格医疗保健项目中2083例患者的处方模式、使用情况、短期结局及广泛应用的意义
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