Bernard P, Vire O, Catanzano G, Bonnetblanc J M
Ann Med Interne (Paris). 1985;136(7):559-65.
Ten personal cases of necrotizing cellulitis and fasciitis are reported. The lower limbs were the most common site of infection. Two patients had involvement of the whole of the leg and died of septic shock. Two other patients died of pulmonary embolism. Bacteriological investigations showed multiple infection to be the rule; gangrene due to streptococcal infection alone was only observed in 3 cases, staphylococcus alone in 1 case and serratia alone in 1 case. Surgery was performed within 48 hours of admission under antibiotic cover in all but two cases. The authors emphasize the need for adequate anticoagulation to prevent multiple venous thrombosis in the infected subcutaneous tissues and to avoid the risk of fatal pulmonary embolism.
报告了10例坏死性蜂窝织炎和筋膜炎的个人病例。下肢是最常见的感染部位。两名患者整个腿部受累,死于感染性休克。另外两名患者死于肺栓塞。细菌学调查显示多重感染是常见情况;仅由链球菌感染引起的坏疽仅在3例中观察到,仅由葡萄球菌引起的坏疽在1例中观察到,仅由沙雷氏菌引起的坏疽在1例中观察到。除两例外,所有病例均在入院后48小时内接受抗生素覆盖下的手术。作者强调需要进行充分的抗凝治疗,以预防感染的皮下组织中出现多发性静脉血栓形成,并避免致命肺栓塞的风险。