Manstein C H, Steerman P H, Goldstein J
Ann Plast Surg. 1985 Aug;15(2):161-2. doi: 10.1097/00000637-198508000-00012.
Sodium warfarin is one of the most commonly used oral anticoagulants. It is not without complications. A case is presented of a 56-year-old woman on well-regulated sodium warfarin therapy who suffered unexplained necrosis and gangrene of the breast. She underwent total mastectomy for debridement because of the extensive nature of the infarction. Possible pathophysiological mechanisms for this process are discussed.
华法林钠是最常用的口服抗凝剂之一。它并非没有并发症。本文报告了一例56岁女性病例，该患者接受华法林钠治疗且病情控制良好，但却出现了不明原因的乳腺坏死和坏疽。由于梗死范围广泛，她接受了全乳切除术以进行清创。本文讨论了这一过程可能的病理生理机制。
