Shnider M, D'Souza C R
Can J Surg. 1976 Jan;19(1):64-5,68.
Sodium warfarin was administered to a 59-year-old woman with congestive cardiac failure and deep vein thrombosis. After 3 days of therapy the nipple and areola of the left breast became inflamed; the entire breast then became necrotic. Gangrene spread and a simple mastectomy was performed. The patient died from pulmonary embolism 1 day after operation. Histologic examination of the breast revealed thrombi in some of the arteries and veins. The etiology of this condition is obscure, and there is no known way of preventing or effectively treating the condition. Simple mastectomy or more conservative local excision recommended.
对一名患有充血性心力衰竭和深静脉血栓形成的59岁女性给予华法林钠治疗。治疗3天后，左乳房乳头和乳晕发炎；随后整个乳房坏死。坏疽扩散，遂行单纯乳房切除术。患者术后1天死于肺栓塞。乳房组织学检查显示一些动静脉内有血栓形成。这种情况的病因不明，且尚无已知的预防或有效治疗方法。建议行单纯乳房切除术或更保守的局部切除术。
