Kurosky Samantha K, Atkinson Christian, Jagun Oladayo, Cooper Charley, Lejeune Alexandre, Castellano Giorgio, Reynolds Neil, Llamado Lyndon, Makgoeng Solomon, de Castro Caio Cesar Silva, Parsad Davinder, Raboobee Noufal, Gao Xing-Hua, Lemeshow Adina R
Pfizer Inc, New York, NY, USA.
Adelphi Real World, Bollington, UK.
J Dermatolog Treat. 2025 Dec;36(1):2555198. doi: 10.1080/09546634.2025.2555198. Epub 2025 Sep 7.
Vitiligo is an autoimmune disease resulting in skin depigmentation and individuals report substantial psychosocial burden. However, vitiligo-related quality of life impacts appear heterogeneous and may be influenced by social determinants of health. This cross-sectional survey aimed to describe characteristics and vitiligo-related quality of life impacts among adults in Brazil, China, India, and South Africa.
Results were stratified by country and examined by bivariate analysis.
Respondents ( = 2202) were mean (standard deviation) 36.9 (11.5) years of age. The most frequently reported income quartile was the highest quartile in China, India, and South Africa, and second-lowest quartile in Brazil. Mean time since initial diagnosis was 11.7 years. Mean % body surface area with depigmentation ranged from 3.7% (China) to 9.7% (South Africa). Mean Dermatology Life Quality Index scores ranged from 5.8 in Brazil to 10.3 in India, indicating a 'moderate' effect of vitiligo on quality-of-life; for 32.3% of respondents, vitiligo had a 'very-to-extremely large' impact on quality-of-life. Mean daily activity impairment was 28.9%. Employed participants reported mean work impairment of 35.6%. Adults with vitiligo in Brazil, China, India, and South Africa reported diverse demographic, socioeconomic, and clinical characteristics.
Overall, vitiligo had a moderate impact on quality of life and was associated with reduced work productivity and activity impairments.
白癜风是一种导致皮肤色素脱失的自身免疫性疾病，患者报告有严重的心理社会负担。然而，白癜风对生活质量的影响似乎存在异质性，可能受到健康的社会决定因素的影响。这项横断面调查旨在描述巴西、中国、印度和南非成年人的特征以及白癜风对生活质量的影响。
结果按国家分层，并通过双变量分析进行检验。
受访者（n = 2202）的平均年龄（标准差）为36.9（11.5）岁。在中国、印度和南非，最常报告的收入四分位数是最高四分位数，在巴西是第二低四分位数。自初次诊断以来的平均时间为11.7年。色素脱失的平均体表面积百分比范围从3.7%（中国）到9.7%（南非）。皮肤病生活质量指数的平均得分范围从巴西的5.8到印度的10.3，表明白癜风对生活质量有“中度”影响；32.3%的受访者表示，白癜风对生活质量有“非常大到极其大”的影响。平均日常活动障碍为28.9%。就业参与者报告的平均工作障碍为35.6%。巴西、中国、印度和南非的白癜风成年人报告了不同的人口统计学、社会经济和临床特征。
总体而言，白癜风对生活质量有中度影响，并与工作效率降低和活动障碍有关。
