Fernandes Bruna Barros, da Silva Larissa Espindola, Willemann Stefanny da Silva, Steiner Mariella Reinol, de Oliveira Mariana Pacheco, Machado Richard Simon, Cidral-Filho Francisco J, Porter Patrick, Martins Daniel Fernandes, Rezin Gislaine Tezza
Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, SC, Brazil.
Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Extreme South of Santa Catarina, Criciúma, SC, Brazil.
J Metab Bariatr Surg. 2025 Aug;14(2):106-123. doi: 10.17476/jmbs.2025.14.2.106. Epub 2025 Aug 22.
Obesity is a chronic inflammatory disease with an alarming number of cases recorded, becoming a global public health problem. Thus, an increasing number of eligible individuals choose to undergo metabolic and bariatric surgery (MBS), known for its effective results in weight reduction and improvement of metabolic conditions. Despite reversing the damage to the central nervous system caused by obesity, these procedures also present neuronal complications. Therefore, in this review, we explore the early impact of MBS on the brain of postoperative patients, with effects observed up to 6 months after surgery, covering hormonal changes, reward mechanisms, as well as influence on mood and mental health. Although improvements in mood and quality of life are reported, the early postoperative phases can be marked by emotional vulnerability, nutritional deficiencies, and psychiatric complications. These findings highlight the benefits and risks associated with MBS, underscoring the need for interventions to maintain quality of life in the postoperative period.
肥胖是一种慢性炎症性疾病，病例数量惊人，已成为一个全球性的公共卫生问题。因此，越来越多符合条件的人选择接受代谢和减重手术（MBS），该手术以其在减轻体重和改善代谢状况方面的显著效果而闻名。尽管这些手术能逆转肥胖对中枢神经系统造成的损害，但也会引发神经元并发症。因此，在本综述中，我们探讨了MBS对术后患者大脑的早期影响，观察到的影响可持续至术后6个月，涵盖激素变化、奖赏机制以及对情绪和心理健康的影响。尽管有报告称情绪和生活质量有所改善，但术后早期阶段可能会出现情绪脆弱、营养缺乏和精神并发症。这些发现凸显了MBS相关的益处和风险，强调了在术后阶段进行干预以维持生活质量的必要性。
