使用广角扫频光学相干断层扫描技术评估非增殖性糖尿病视网膜病变中的视网膜水肿

Evaluation of Retinal Edema in Nonproliferative Diabetic Retinopathy Using Widefield Swept-Source OCT.

作者信息

Chiku Yoshiaki, Hirano Takao, Hoshiyama Ken, Murata Toshinori

机构信息

Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.

出版信息

Ophthalmol Sci. 2025 Jul 17;5(6):100888. doi: 10.1016/j.xops.2025.100888. eCollection 2025 Nov-Dec.

DOI:10.1016/j.xops.2025.100888

PMID:40917263

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12410537/

Abstract

PURPOSE

This study evaluates retinal volume in the macula and peripheral retina in patients with nonproliferative diabetic retinopathy (NPDR), with and without diabetic macular edema (DME), using widefield swept-source OCT (SS-OCT).

DESIGN

Retrospective observational study.

PARTICIPANTS

A total of 98 eyes were included: 30 from patients with NPDR without DME (DME-), 38 from patients with NPDR with DME (DME+), and 30 from age- and sex-matched healthy controls.

METHODS

OCT examinations used SS-OCT (Xephilio OCT-S1; Canon) to capture 23 × 20 mm (1024 × 128 A-scans) cube images. Retinal volume was calculated for each sector in a 9-sector grid defined by concentric circles (1 mm, 6 mm, and 20 mm in diameter) centered on the fovea and divided into four quadrants: superior, inferior, nasal, and temporal. The macular region was defined within a 6-mm diameter, whereas the peripheral retina spanned 6 mm to 20 mm.

MAIN OUTCOME MEASURES

Macular and peripheral retinal volumes measured from SS-OCT images in each group.

RESULTS

A total of 98 eyes were analyzed (control: 30; DME-: 30; DME+: 38). Macular retinal volume was 8.46 ± 0.49 mm in the control group, 8.79 ± 0.55 mm in the DME-group, and significantly higher at 10.53 ± 1.81 mm in the DME + group ( < 0.0001). Peripheral retinal volume was 64.5 ± 3.1 mm in the control group, 62.2 ± 3.7 mm in the DME-group, and significantly higher at 68.7 ± 10.4 mm in the DME + group ( < 0.001). In DME+, severe NPDR showed greater volumes (macula: 11.2 ± 1.9 mm; periphery: 71.9 ± 13.0 mm) than mild-to-moderate NPDR (macula: 9.67 ± 1.14 mm; periphery: 65.1 ± 4.6 mm; < 0.01 and < 0.05, respectively).

CONCLUSIONS

Our findings indicate that retinal volume increases in both macular and peripheral regions in DME, particularly as NPDR severity progresses.

FINANCIAL DISCLOSURES

The author has no/the authors have no proprietary or commercial interest in any materials discussed in this article.

摘要

目的

本研究使用广角扫频光学相干断层扫描（SS-OCT）评估非增殖性糖尿病视网膜病变（NPDR）患者有无糖尿病性黄斑水肿（DME）时黄斑区和周边视网膜的体积。

设计

回顾性观察研究。

参与者

共纳入98只眼：30只来自无DME的NPDR患者（DME-），38只来自有DME的NPDR患者（DME+），以及30只年龄和性别匹配的健康对照者的眼睛。

方法

OCT检查使用SS-OCT（Xephilio OCT-S1；佳能）获取23×20 mm（1024×128 A线扫描）的立方体图像。以黄斑中心凹为中心，由同心圆（直径1 mm、6 mm和20 mm）定义一个9扇区网格，将其分为四个象限：上、下、鼻侧和颞侧，计算每个扇区的视网膜体积。黄斑区定义为直径6 mm范围内，而周边视网膜范围为6 mm至20 mm。

主要观察指标

每组通过SS-OCT图像测量的黄斑和周边视网膜体积。

结果

共分析98只眼（对照组：30只；DME-组：30只；DME+组：38只）。对照组黄斑视网膜体积为8.46±0.49 mm，DME-组为8.79±0.55 mm，DME+组显著更高，为10.53±1.81 mm（P<0.0001）。对照组周边视网膜体积为64.5±3.1 mm，DME-组为62.2±3.7 mm，DME+组显著更高，为68.7±10.4 mm（P<0.001）。在DME+组中，重度NPDR的体积（黄斑区：11.2±1.9 mm；周边：71.9±13.0 mm）大于轻度至中度NPDR（黄斑区：9.67±1.14 mm；周边：65.1±4.6 mm；P分别<0.01和<0.05）。