Chiku Yoshiaki, Hirano Takao, Hoshiyama Ken, Murata Toshinori
Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Ophthalmol Sci. 2025 Jul 17;5(6):100888. doi: 10.1016/j.xops.2025.100888. eCollection 2025 Nov-Dec.
This study evaluates retinal volume in the macula and peripheral retina in patients with nonproliferative diabetic retinopathy (NPDR), with and without diabetic macular edema (DME), using widefield swept-source OCT (SS-OCT).
Retrospective observational study.
A total of 98 eyes were included: 30 from patients with NPDR without DME (DME-), 38 from patients with NPDR with DME (DME+), and 30 from age- and sex-matched healthy controls.
OCT examinations used SS-OCT (Xephilio OCT-S1; Canon) to capture 23 × 20 mm (1024 × 128 A-scans) cube images. Retinal volume was calculated for each sector in a 9-sector grid defined by concentric circles (1 mm, 6 mm, and 20 mm in diameter) centered on the fovea and divided into four quadrants: superior, inferior, nasal, and temporal. The macular region was defined within a 6-mm diameter, whereas the peripheral retina spanned 6 mm to 20 mm.
Macular and peripheral retinal volumes measured from SS-OCT images in each group.
A total of 98 eyes were analyzed (control: 30; DME-: 30; DME+: 38). Macular retinal volume was 8.46 ± 0.49 mm in the control group, 8.79 ± 0.55 mm in the DME-group, and significantly higher at 10.53 ± 1.81 mm in the DME + group ( < 0.0001). Peripheral retinal volume was 64.5 ± 3.1 mm in the control group, 62.2 ± 3.7 mm in the DME-group, and significantly higher at 68.7 ± 10.4 mm in the DME + group ( < 0.001). In DME+, severe NPDR showed greater volumes (macula: 11.2 ± 1.9 mm; periphery: 71.9 ± 13.0 mm) than mild-to-moderate NPDR (macula: 9.67 ± 1.14 mm; periphery: 65.1 ± 4.6 mm; < 0.01 and < 0.05, respectively).
Our findings indicate that retinal volume increases in both macular and peripheral regions in DME, particularly as NPDR severity progresses.
The author has no/the authors have no proprietary or commercial interest in any materials discussed in this article.
本研究使用广角扫频光学相干断层扫描（SS-OCT）评估非增殖性糖尿病视网膜病变（NPDR）患者有无糖尿病性黄斑水肿（DME）时黄斑区和周边视网膜的体积。
回顾性观察研究。
共纳入98只眼：30只来自无DME的NPDR患者（DME-），38只来自有DME的NPDR患者（DME+），以及30只年龄和性别匹配的健康对照者的眼睛。
OCT检查使用SS-OCT（Xephilio OCT-S1；佳能）获取23×20 mm（1024×128 A线扫描）的立方体图像。以黄斑中心凹为中心，由同心圆（直径1 mm、6 mm和20 mm）定义一个9扇区网格，将其分为四个象限：上、下、鼻侧和颞侧，计算每个扇区的视网膜体积。黄斑区定义为直径6 mm范围内，而周边视网膜范围为6 mm至20 mm。
每组通过SS-OCT图像测量的黄斑和周边视网膜体积。
共分析98只眼（对照组：30只；DME-组：30只；DME+组：38只）。对照组黄斑视网膜体积为8.46±0.49 mm，DME-组为8.79±0.55 mm，DME+组显著更高，为10.53±1.81 mm（P<0.0001）。对照组周边视网膜体积为64.5±3.1 mm，DME-组为62.2±3.7 mm，DME+组显著更高，为68.7±10.4 mm（P<0.001）。在DME+组中，重度NPDR的体积（黄斑区：11.2±1.9 mm；周边：71.9±13.0 mm）大于轻度至中度NPDR（黄斑区：9.67±1.14 mm；周边：65.1±4.6 mm；P分别<0.01和<0.05）。
我们的研究结果表明，DME患者的黄斑区和周边区域视网膜体积均增加，尤其是随着NPDR严重程度的进展。
作者对本文讨论的任何材料均无/作者们对本文讨论的任何材料均无专利或商业利益。
