Hirasawa Kazunori, Yamaguchi Jun, Nagano Koichi, Kanno Junji, Kasahara Masayuki, Shoji Nobuyuki
Department of Ophthalmology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan.
Ophthalmol Sci. 2022 Jan 30;2(2):100120. doi: 10.1016/j.xops.2022.100120. eCollection 2022 Jun.
To investigate the effects of adjusting the ocular magnification during OCT-based angiography imaging on structure-function relationships and glaucoma detection.
Cross-sectional study.
A total of 96 healthy control participants and 90 patients with open-angle glaucoma were included.
One eye of each patient in the control group and the patient group was evaluated. The layers comprising the macula vascular density (VD) and circumpapillary VD were derived from swept-source OCT angiography imaging. The mean sensitivity (MS) of the standard automated perimetry was measured using the Humphrey 24-2 test. Structure-function relationships were evaluated with simple and partial correlation coefficients. A receiver operating characteristic analysis was performed to evaluate the diagnostic accuracy for glaucoma using the area under the receiver operating characteristic curve (AUC). Ocular magnification was adjusted using Littmann's formula modified by Bennett.
The association between the axial length and VD, structure-function relationships, and glaucoma detection with and without magnification correction.
The superficial layer of the macular region was not significantly correlated to the axial length without magnification correction ( = 0.0011; = 0.99); however, it was negatively correlated to the axial length with magnification correction ( = -0.22; = 0.028). Regarding the nerve head layer in the circumpapillary region, a negative correlation to the axial length without magnification correction was observed ( = -0.22; = 0.031); however, this significant correlation disappeared with magnification correction. The superficial layer of the macula and the nerve head layer of the circumpapillary region were significantly correlated to Humphrey 24-2 MS values without magnification correction ( = 0.22 and = 0.32, respectively); however, these correlations did not improve after magnification correction ( = 0.20 and = 0.33, respectively). Glaucoma diagnostic accuracy in the superficial layer (AUC, 0.63) and nerve head layer (AUC, 0.70) without magnification correction did not improve after magnification correction (AUC, 0.62 and 0.69, respectively).
Adjustment of the ocular magnification is important for accurate VD measurements; however, it may not significantly impact structure-function relationships and glaucoma detection.
研究在基于光学相干断层扫描血管造影成像过程中调整眼放大倍数对结构-功能关系及青光眼检测的影响。
横断面研究。
共纳入96名健康对照者和90名开角型青光眼患者。
对对照组和患者组中每位患者的一只眼睛进行评估。通过扫频源光学相干断层扫描血管造影成像获取包括黄斑区血管密度（VD）和视盘周围VD的各层图像。使用Humphrey 24-2检测法测量标准自动视野计的平均敏感度（MS）。用简单相关系数和偏相关系数评估结构-功能关系。进行受试者工作特征分析，使用受试者工作特征曲线下面积（AUC）评估青光眼的诊断准确性。使用由Bennett修改的Littmann公式调整眼放大倍数。
轴长与VD之间的关联、结构-功能关系以及有无放大倍数校正时的青光眼检测情况。
在未进行放大倍数校正时，黄斑区表层与轴长无显著相关性（r = 0.0011；P = 0.99）；然而，在进行放大倍数校正后，它与轴长呈负相关（r = -0.22；P = 0.028）。关于视盘周围区域的神经纤维层，在未进行放大倍数校正时观察到其与轴长呈负相关（r = -0.22；P = 0.031）；然而，这种显著相关性在进行放大倍数校正后消失。在未进行放大倍数校正时，黄斑区表层和视盘周围区域的神经纤维层与Humphrey 24-2 MS值显著相关（分别为r = 0.22和r = 0.32）；然而，在进行放大倍数校正后，这些相关性并未改善（分别为r = 0.20和r = 0.33）。在未进行放大倍数校正时，表层（AUC，0.63）和神经纤维层（AUC，0.70）的青光眼诊断准确性在进行放大倍数校正后并未提高（分别为AUC，0.62和0.69）。
调整眼放大倍数对于准确测量VD很重要；然而，它可能不会对结构-功能关系和青光眼检测产生显著影响。
