Does p-tau217 play a physiological reparative role in neonates and neurodegenerative diseases?
作者信息
Daly Timothy, Pini Lorenzo, Imbimbo Bruno P
机构信息
UMR 1219 Bordeaux Population Health, Université de Bordeaux & INSERM, Bordeaux 33076, France.
UMR 5164, ImmunoConcept, University of Bordeaux & CNRS, Bordeaux 33076, France.
出版信息
Brain Commun. 2025 Aug 25;7(5):fcaf321. doi: 10.1093/braincomms/fcaf321. eCollection 2025.
Abstract
摘要
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Does p-tau217 play a physiological reparative role in neonates and neurodegenerative diseases?磷酸化tau蛋白217（p-tau217）在新生儿和神经退行性疾病中是否发挥生理修复作用？
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本文引用的文献
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The potential dual role of tau phosphorylation: plasma phosphorylated-tau217 in newborns and Alzheimer's disease.tau蛋白磷酸化的潜在双重作用：新生儿和阿尔茨海默病中的血浆磷酸化tau217
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Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer's pathology.携带神经原纤维缠结的神经元在阿尔茨海默病病理小鼠中细胞死亡风险降低。
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Alzheimers Dement. 2023 Jul;19(7):2874-2887. doi: 10.1002/alz.12892. Epub 2023 Jan 12.
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Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS.调控哺乳动物中枢神经系统发育过程中活性依赖型突触修剪的机制。
Nat Rev Neurosci. 2021 Nov;22(11):657-673. doi: 10.1038/s41583-021-00507-y. Epub 2021 Sep 20.
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A current view on Tau protein phosphorylation in Alzheimer's disease.阿尔茨海默病中 Tau 蛋白磷酸化的最新观点。
Curr Opin Neurobiol. 2021 Aug;69:131-138. doi: 10.1016/j.conb.2021.03.003. Epub 2021 Apr 21.
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The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method.使用Phos-Tag方法揭示小鼠和人类tau蛋白病大脑中未磷酸化tau蛋白的丰度。
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