Edmondson Anna, Beresford Charley, Harmsen Jan-Frieder
MRC Laboratory of Molecular Biology Cambridge, Cambridge, UK.
Healthy Living Spaces Lab, Institute for Occupational, Social and Environmental Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.
NPJ Biol Timing Sleep. 2025;2(1):32. doi: 10.1038/s44323-025-00048-y. Epub 2025 Sep 4.
The retinal photopigment melanopsin is also expressed in subcutaneous white adipose tissue (scWAT). Through melanopsin, light can modulate scWAT metabolism, but its impact on circadian phase is unclear. In vitro exposure of murine scWAT to bright light at different times over 24 h did not elicit phase shifts, unlike the response to corticosterone. This finding suggests that the direct impact of bright light on scWAT metabolism occurs in a circadian-independent manner.
视网膜光色素黑视蛋白也在皮下白色脂肪组织（scWAT）中表达。通过黑视蛋白，光线可以调节scWAT的代谢，但其对昼夜节律相位的影响尚不清楚。与对皮质酮的反应不同，在24小时内的不同时间将小鼠scWAT体外暴露于强光下并未引起相位偏移。这一发现表明，强光对scWAT代谢的直接影响是以一种不依赖昼夜节律的方式发生的。
