Abdollahi Omid, Vosoughi Tina, Talebi Afshin, Karimpourian Hossein, Rastegar Mohammadhossein, Farhadi Elham
Department of Internal Medicine, School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran.
Thalassemia & Hemoglobinopathy Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran.
Health Sci Rep. 2025 Sep 4;8(9):e71208. doi: 10.1002/hsr2.71208. eCollection 2025 Sep.
Cancer is currently recognized as one of the leading causes of mortality worldwide. Given the limited understanding of the association between elevated erythrocyte sedimentation rate (ESR) and solid tumors (STs), this study aimed to examine ESR values at the time of malignancy diagnosis.
This cross-sectional study utilized data extracted from the medical records of cancer patients at Shahid Baghaei-2 Hospital and Shafa Hospital in Ahvaz, Iran, from February 2020 to October 2021. Patients diagnosed with leukemia, lymphoma, or multiple myeloma (MM) were excluded from the analysis. The ESR values, measured during the first hour at the onset of ST diagnosis, were documented. This is because in Iranian laboratories, ESR is checked during the first hour. Subsequently, patients were categorized based on age, gender, type of malignancy, and disease stage.
Of the 428 cancer patients included, 259 (60.5%) were female. One-way analysis of variance (ANOVA) revealed a statistically significant difference between the type of malignancy and ESR values at the time of ST diagnosis ( = 0.02). Notably, ESR levels were significantly elevated in patients with gastric and ovarian cancers compared to other cancer types. Additionally, a significant association was observed between ESR values and disease stage ( = 0.004).
This study demonstrated that ESR levels at the time of diagnosis were significantly associated with both the type and stage of STs. Higher ESR values were particularly evident in patients with gastric and ovarian cancers, as well as those in advanced disease stages, suggesting ESR may serve as a useful prognostic indicator in cancer assessment.
癌症目前被认为是全球主要的死亡原因之一。鉴于对红细胞沉降率（ESR）升高与实体瘤（STs）之间关联的了解有限，本研究旨在检查恶性肿瘤诊断时的ESR值。
这项横断面研究利用了从伊朗阿瓦士的沙希德·巴盖伊 - 2医院和沙法医院2020年2月至2021年10月癌症患者的病历中提取的数据。诊断为白血病、淋巴瘤或多发性骨髓瘤（MM）的患者被排除在分析之外。记录了在ST诊断开始时第一小时测量的ESR值。这是因为在伊朗实验室，ESR是在第一小时进行检查的。随后，根据年龄、性别、恶性肿瘤类型和疾病阶段对患者进行分类。
在纳入的428例癌症患者中，259例（60.5%）为女性。单因素方差分析（ANOVA）显示，恶性肿瘤类型与ST诊断时的ESR值之间存在统计学显著差异（= 0.02）。值得注意的是，与其他癌症类型相比，胃癌和卵巢癌患者的ESR水平显著升高。此外，ESR值与疾病阶段之间存在显著关联（= 0.004）。
本研究表明，诊断时的ESR水平与STs的类型和阶段均显著相关。较高的ESR值在胃癌和卵巢癌患者以及疾病晚期患者中尤为明显，表明ESR可能作为癌症评估中有用的预后指标。
