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假尿苷糖苷酶对于在潮霉素胁迫下的生长以及丝状化很重要。

pseudouridine glycosidase is important for growth in hygromycin stress and for filamentation.

作者信息

Walther Rheanna E, Singh Emeline, Bernstein Douglas A

机构信息

Biology, Ball State University, Muncie, Indiana, United States.

出版信息

MicroPubl Biol. 2025 Aug 21;2025. doi: 10.17912/micropub.biology.001713. eCollection 2025.

DOI:10.17912/micropub.biology.001713
PMID:40918428
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12411936/
Abstract

When an RNA is no longer needed or has become damaged, it is degraded to its single base components. Pseudouridine is found in all domains of life and is found in a variety of types of RNA. Pseudouridine has ribose and uracil moieties attached via a C-C bond. Cleavage of this bond is performed by pseudouridine glycosidases. We find deletion of the pseudouridine glycosidase from the human fungal pathogen leads to sensitivity to hygromycin and changes to filamentation. In addition, deletion of pseudouridine glycosidase leads to the upregulation of several permeases. Our data suggest pseudouridine glycosidases are important for fitness.

摘要

当RNA不再被需要或已受损时，它会被降解为单个碱基成分。假尿苷存在于所有生命域中，并且存在于多种类型的RNA中。假尿苷的核糖和尿嘧啶部分通过碳-碳键相连。这种键的断裂由假尿苷糖苷酶进行。我们发现从人类真菌病原体中删除假尿苷糖苷酶会导致对潮霉素敏感并改变丝状化。此外，删除假尿苷糖苷酶会导致几种通透酶的上调。我们的数据表明假尿苷糖苷酶对适应性很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac9/12411936/e9479fcb7fa8/25789430-2025-micropub.biology.001713.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac9/12411936/e9479fcb7fa8/25789430-2025-micropub.biology.001713.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac9/12411936/e9479fcb7fa8/25789430-2025-micropub.biology.001713.jpg

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本文引用的文献

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Pseudouridine Modifications in Transfer RNA and tRNA Pseudouridine Synthases.转运RNA中的假尿苷修饰与tRNA假尿苷合酶
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The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines.假尿苷对新冠病毒mRNA疫苗的关键作用
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