Matoo Samaneh, Acharya Prashun, Tonu Sadika T J, Bharaj Jasvinder, Mudaliyar Ashwini, Touny Basmala, VanderPol Regan, Timms Morgan, Dyko Nicole, Asante Domtie, Abdulle Hawa, Crawley Scott W
Molecular, Cellular and Developmental Biology, University of Toledo, Toledo, Ohio, United States.
MicroPubl Biol. 2025 Aug 22;2025. doi: 10.17912/micropub.biology.001663. eCollection 2025.
Cadherin-related family member 5 (CDHR5) is a protocadherin found enriched at the tips of brush border microvilli of the gut and kidney, where it plays an important role in the development of these specialized microvilli. CDHR5 is a type-1 transmembrane protein with a short cytoplasmic tail that contains a number of poly-proline motifs of unknown function. We performed an analysis of the poly-proline stretches in the CDHR5 cytoplasmic tail and show that mutation of these motifs does not largely influence the targeting of CDHR5 to microvilli, but does significantly impact the ability of the cadherin to promote microvillar elongation.
钙黏蛋白相关家族成员5（CDHR5）是一种原钙黏蛋白，在肠道和肾脏的刷状缘微绒毛尖端富集，在这些特殊微绒毛的发育中发挥重要作用。CDHR5是一种1型跨膜蛋白，其短细胞质尾巴包含多个功能未知的多聚脯氨酸基序。我们对CDHR5细胞质尾巴中的多聚脯氨酸片段进行了分析，结果表明这些基序的突变在很大程度上不影响CDHR5靶向微绒毛，但确实会显著影响钙黏蛋白促进微绒毛伸长的能力。
