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Off-label treatment with miltefosine for complex, pediatric Old World cutaneous leishmaniasis.

作者信息

Buchelt Marlene, Valero Teresa, Kinaciyan Tamar, Walochnik Julia, Egg Maximilian, Szelenyi Anna, Langer Sophie, Handisurya Alessandra

机构信息

Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

出版信息

JAAD Case Rep. 2025 Jul 30;64:26-29. doi: 10.1016/j.jdcr.2025.05.054. eCollection 2025 Oct.

DOI:10.1016/j.jdcr.2025.05.054
PMID:40918544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12410488/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd6/12410488/dc2cdb31cc46/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd6/12410488/9924655b243c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd6/12410488/636ad787a3bd/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd6/12410488/dc2cdb31cc46/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd6/12410488/9924655b243c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd6/12410488/636ad787a3bd/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd6/12410488/dc2cdb31cc46/gr3.jpg

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本文引用的文献

1
Progress in antileishmanial drugs: Mechanisms, challenges, and prospects.抗利什曼原虫药物的进展：作用机制、挑战与前景
PLoS Negl Trop Dis. 2025 Jan 3;19(1):e0012735. doi: 10.1371/journal.pntd.0012735. eCollection 2025 Jan.
2
The changing epidemiology of human leishmaniasis in the non-endemic country of Austria between 2000 to 2021, including a congenital case.2000 年至 2021 年期间，奥地利这一非流行国家的人利什曼病的流行情况发生变化，包括 1 例先天性病例。
PLoS Negl Trop Dis. 2024 Jan 10;18(1):e0011875. doi: 10.1371/journal.pntd.0011875. eCollection 2024 Jan.
3
Review of the Clinical Presentation, Pathology, Diagnosis, and Treatment of Leishmaniasis.
利什曼病的临床特征、病理学、诊断和治疗的综述。
Lab Med. 2023 Jul 5;54(4):363-371. doi: 10.1093/labmed/lmac134.
4
Cutaneous Leishmaniasis Treated with Miltefosine: A Case Series of 10 Paediatric Patients.米替福新治疗皮肤利什曼病：10 例儿科患者的病例系列。
Acta Derm Venereol. 2020 Oct 19;100(18):adv00322. doi: 10.2340/00015555-3669.
5
Interventions to treat cutaneous leishmaniasis in children: A systematic review.干预措施治疗儿童皮肤利什曼病：系统评价。
PLoS Negl Trop Dis. 2018 Dec 14;12(12):e0006986. doi: 10.1371/journal.pntd.0006986. eCollection 2018 Dec.
6
Pharmacokinetics of Miltefosine in Children and Adults with Cutaneous Leishmaniasis.米替福新在儿童和成人皮肤利什曼病患者中的药代动力学。
Antimicrob Agents Chemother. 2017 Feb 23;61(3). doi: 10.1128/AAC.02198-16. Print 2017 Mar.
7
Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH).利什曼病的诊断与治疗：美国传染病学会（IDSA）和美国热带医学与卫生学会（ASTMH）发布的临床实践指南
Am J Trop Med Hyg. 2017 Jan 11;96(1):24-45. doi: 10.4269/ajtmh.16-84256. Epub 2016 Dec 7.
8
Failure of miltefosine in visceral leishmaniasis is associated with low drug exposure.米替福新治疗内脏利什曼病失败与药物暴露量低有关。
J Infect Dis. 2014 Jul 1;210(1):146-53. doi: 10.1093/infdis/jiu039. Epub 2014 Jan 16.
9
Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children.米替福新对比葡甲胺锑治疗儿童皮肤利什曼病的非劣效性。
J Infect Dis. 2012 Feb 15;205(4):684-92. doi: 10.1093/infdis/jir816. Epub 2012 Jan 11.
10
Randomized controlled clinical trial to access efficacy and safety of miltefosine in the treatment of cutaneous leishmaniasis Caused by Leishmania (Viannia) guyanensis in Manaus, Brazil.随机对照临床试验评估米替福新治疗巴西玛瑙斯地区由圭亚那利什曼原虫引起的皮肤利什曼病的疗效和安全性。
Am J Trop Med Hyg. 2011 Feb;84(2):255-60. doi: 10.4269/ajtmh.2011.10-0155.