Structure-activity relationships of dermorphin tetrapeptides carrying a ketomethylene linkage.
作者信息
Marastoni M, Balboni G, Salvadori S, Sarto G P, Tomatis R
出版信息
Arzneimittelforschung. 1985;35(11):1630-2.
PMID:4091867
Abstract
The synthesis and in vitro pharmacological tests of 5 ketomethylene tetrapeptide analogues of the opioid heptapeptide dermorphin H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 are described in this study. The substitution of the original Phe-Gly peptide bond (-CO-NH-) by the ketomethylene linkage (-CO-CH2-) provided analogues with reduced opioid activity.
摘要
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