阿片样肽。皮啡肽内硫代四肽的构效关系。VII。
Opioid peptides. Structure-activity relationships of dermorphin endothiotetrapeptides. VII.
作者信息
Salvadori S, Marastoni M, Balboni G, Tomatis R, Sarto G
出版信息
Farmaco Sci. 1984 Apr;39(4):316-21.
PMID:6144571
Abstract
We describe the synthesis and preliminary in vitro and in vivo pharmacological tests of five endothiotetrapeptide analogues of the opioid heptapeptide dermorphin H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser.-NH2. The modification obtained by substituting Phet for Phe3 or Glyt for Gly4 provided further analogues with significant opioid activity.
摘要
我们描述了阿片样七肽皮啡肽H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser.-NH2的五种内硫代四肽类似物的合成以及初步的体外和体内药理学测试。用Phet取代Phe3或用Glyt取代Gly4所得到的修饰产生了具有显著阿片样活性的其他类似物。
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