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揭开毛发角化病的面纱:对其起源、管理策略及研究前沿的见解

Keratosis Pilaris Unveiled: Insights into its Origin, Management Strategies and Research Frontiers.

作者信息

Kaur Komalpreet, Kaur Amrinder, Kalsi Vandna, Kasav Shivalika

机构信息

From the Department of Ayurveda, School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar, Punjab, India.

Department of Pharmacognosy, School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar, Punjab, India.

出版信息

Indian J Dermatol. 2025 Sep-Oct;70(5):267-274. doi: 10.4103/ijd.ijd_51_25. Epub 2025 Sep 1.

Abstract

Follicular hyperkeratosis is frequently known as keratosis pilaris (KP). Small, folliculocentric keratotic papules with possible erythematous borders are its defining features. It is a common, asymptomatic skin disorder. The tiny papules give the skin a stippled, gooseflesh-like appearance. The disorder most frequently affects the exterior portions of the upper arms, upper legs and buttocks. It is caused by prolonged exposure to the sun and people suffering from dry skin. The consequences of KP disease are mainly triggered by dryness and rough skin, which results in bumpy skin, redness, irritation, itching and hyperpigmentation. It can affect persons of any age, but it is more prevalent in children and teenagers. While the classic KP is known, the other variants are also there which have particular effects on the different parts of the body. To alleviate symptoms, apply moisturizers, exfoliates and topical treatments containing urea, lactic acid or salicylic acid. This critical issue must be addressed; there have been very few clinical studies, and this study will assist researchers in carrying out more clinical trials and studies on KP disorder. Being aware of KP is a very important point while it is not entirely preventable, using regular moisturizer, keeping gentle exfoliation and the use of light cleansers can all help to manage and reduce its appearance. There are a few current therapies used to treat the disease, including laser and blue light treatments, and photodynamic therapies.

摘要

毛囊性角化过度症通常被称为毛发角化病(KP)。以毛囊为中心的小角化性丘疹,边缘可能呈红斑状,是其特征性表现。它是一种常见的无症状性皮肤病。这些微小的丘疹使皮肤呈现出点状、鸡皮样外观。该疾病最常累及上臂外侧、大腿上部和臀部。它是由长期日晒和干性皮肤人群引起的。毛发角化病的后果主要由皮肤干燥和粗糙引发,导致皮肤凹凸不平、发红、刺激、瘙痒和色素沉着。它可影响任何年龄段的人,但在儿童和青少年中更为普遍。虽然经典的毛发角化病为人所知,但也存在其他变体,它们对身体的不同部位有特定影响。为缓解症状,可涂抹含有尿素、乳酸或水杨酸的保湿剂、去角质剂和局部治疗药物。这个关键问题必须得到解决;目前临床研究很少,而本研究将有助于研究人员对毛发角化病开展更多的临床试验和研究。虽然毛发角化病不能完全预防,但了解它非常重要,使用常规保湿剂、保持温和去角质以及使用温和的洁面产品都有助于控制和减少其外观。目前有一些用于治疗该疾病的疗法,包括激光和蓝光治疗以及光动力疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba3d/12413161/96ad7674eabd/IJD-70-267-g001.jpg

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