Wang Madeline A, Wilson Anna, Murrell Dédée F
Department of Dermatology, St George Hospital, Sydney, NSW, Australia.
Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Skin Appendage Disord. 2023 Aug;9(4):241-251. doi: 10.1159/000529487. Epub 2023 Apr 20.
Disease severity assessment tools play a large part in evaluating skin conditions in dermatology. Currently, there is no existing validated assessment tool for keratosis pilaris (KP), a benign yet highly prevalent follicular disorder. A range of proposed scoring tools have been used in different clinical trials for the assessment of potential treatments for KP. A literature review of the current scoring systems used for KP shows that there is a lack of consistency with most studies using varying versions of unvalidated investigator global assessment (IGA) scores and quartile grading systems. A review of these studies shows that current methods of evaluating KP in clinical trials are subjective, unreliable, and inconsistent. A standardised and validated scoring system would be significant as it could be used in clinical trials to advance the current knowledge of KP.
疾病严重程度评估工具在皮肤科皮肤疾病评估中发挥着重要作用。目前,对于毛发角化病(KP)这一良性但高度常见的毛囊疾病,尚无经过验证的评估工具。一系列提议的评分工具已在不同的临床试验中用于评估KP的潜在治疗方法。对当前用于KP的评分系统的文献综述表明,大多数研究使用未经验证的研究者整体评估(IGA)评分和四分位数分级系统的不同版本,缺乏一致性。对这些研究的回顾表明,目前在临床试验中评估KP的方法具有主观性、不可靠性且不一致。一个标准化且经过验证的评分系统将具有重要意义,因为它可用于临床试验,以增进当前对KP的认识。