The effect of haemodynamic stress on the glycosaminoglycan content of blood vessel walls of experimental aneurysms and arteriovenous fistulae.

The glycosaminoglycan content of experimental saccular aneurysms and arteriovenous fistulae of sheep has been measured. In the experimental aneurysm hyaluronic acid, heparan sulphate, dermatan sulphate, chondroitin sulphate and total glycosaminoglycans were all elevated above control tissue levels with increases most striking for dermatan sulphate and chondroitin sulphate. In the anastomosed vein of the arteriovenous fistulae, total glycosaminoglycans were also significantly raised but which individual glycosaminoglycans were responsible was not clearly established. In the arteries feeding the fistulae, increased chondroitin sulphate in the proximal arterial segment was the only significant change observed. The changes were attributed to altered haemodynamic stresses and are similar to those reported for animal models of hypertension and early human atherosclerosis.