Rogers K M, Merrilees M J, Stehbens W E
Atherosclerosis. 1985 Dec;58(1-3):139-48. doi: 10.1016/0021-9150(85)90061-9.
The glycosaminoglycan content of experimental saccular aneurysms and arteriovenous fistulae of sheep has been measured. In the experimental aneurysm hyaluronic acid, heparan sulphate, dermatan sulphate, chondroitin sulphate and total glycosaminoglycans were all elevated above control tissue levels with increases most striking for dermatan sulphate and chondroitin sulphate. In the anastomosed vein of the arteriovenous fistulae, total glycosaminoglycans were also significantly raised but which individual glycosaminoglycans were responsible was not clearly established. In the arteries feeding the fistulae, increased chondroitin sulphate in the proximal arterial segment was the only significant change observed. The changes were attributed to altered haemodynamic stresses and are similar to those reported for animal models of hypertension and early human atherosclerosis.
已对绵羊实验性囊状动脉瘤和动静脉瘘中的糖胺聚糖含量进行了测量。在实验性动脉瘤中，透明质酸、硫酸乙酰肝素、硫酸皮肤素、硫酸软骨素和总糖胺聚糖均高于对照组织水平，其中硫酸皮肤素和硫酸软骨素的增加最为显著。在动静脉瘘的吻合静脉中，总糖胺聚糖也显著升高，但不清楚是哪些个别糖胺聚糖起了作用。在为瘘管供血的动脉中，近端动脉段硫酸软骨素增加是观察到的唯一显著变化。这些变化归因于血流动力学应力的改变，与高血压动物模型和早期人类动脉粥样硬化所报道的变化相似。
