Marquezini M V, Strunz C M, Dallan L A, Toledo O M
Pró-Sangue Foundation Hemocentro de São Paulo, University of São Paulo School of Medicine, Brazil.
Cardiology. 1995;86(2):143-6. doi: 10.1159/000176860.
Glycosaminoglycan composition of normal saphenous veins and atherosclerotic saphenous vein grafts is reported. Dermatan sulfate is the main glycosaminoglycan present in both normal saphenous veins and saphenous vein grafts. These tissues also contain chondroitin sulfate and heparan sulfate. Although the total amount of glycosaminoglycans decreased in the grafts (compared with normal saphenous veins), the grafts showed an increase in the relative amounts of dermatan sulfate and chondroitin sulfate. Heparan sulfate was decreased, compared with normal controls. These findings suggest the involvement of blood vessel glycosaminoglycans (not only the arterial glycosaminoglycans) in the process of atherosclerosis.
报道了正常大隐静脉和动脉粥样硬化大隐静脉移植物的糖胺聚糖组成。硫酸皮肤素是正常大隐静脉和大隐静脉移植物中存在的主要糖胺聚糖。这些组织还含有硫酸软骨素和硫酸乙酰肝素。尽管移植物中糖胺聚糖的总量减少（与正常大隐静脉相比），但移植物中硫酸皮肤素和硫酸软骨素的相对含量增加。与正常对照相比，硫酸乙酰肝素减少。这些发现表明血管糖胺聚糖（不仅是动脉糖胺聚糖）参与了动脉粥样硬化的过程。
