Aljuba Yahya M, Shatalin Daniel, Ronenson Alexander, Grenader Aharon, Ioscovich Alexander
Department of Anesthesiology, Perioperative Medicine and Pain Treatment, Shaare Zedek Medical Center (Affiliated with the Hebrew University of Jerusalem), Jerusalem, ISR.
Department of Anaesthesiology, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, ISR.
Cureus. 2025 Aug 5;17(8):e89400. doi: 10.7759/cureus.89400. eCollection 2025 Aug.
Pregnancy in women with Ehlers-Danlos syndrome (EDS) carries elevated risks, including prematurity, hemorrhage, and maternal morbidity, posing significant anesthetic challenges. We present the case of a 36-year-old woman with classical EDS (cEDS) and multiple comorbidities, including postural orthostatic tachycardia syndrome, bronchial asthma, congenital adrenal hypoplasia, and chronic venous thrombosis, who underwent an elective cesarean section. A multidisciplinary team developed a comprehensive perioperative plan featuring ultrasound-guided spinal anesthesia, extended post-anesthesia observation, and coordinated recommendations from cardiology, hematology, endocrinology, pulmonology, and other specialties. This report emphasizes the complexity of anesthetic care in EDS pregnancies and underscores the need to tailor management to the specific EDS subtype and individual patient profile.
患有埃勒斯-当洛综合征（EDS）的女性怀孕会带来更高的风险，包括早产、出血和孕产妇发病，这给麻醉带来了重大挑战。我们报告了一例36岁患有经典型EDS（cEDS）且伴有多种合并症的女性病例，这些合并症包括体位性直立性心动过速综合征、支气管哮喘、先天性肾上腺发育不全和慢性静脉血栓形成，该患者接受了择期剖宫产手术。一个多学科团队制定了一份全面的围手术期计划，其特点包括超声引导下的脊髓麻醉、延长麻醉后观察时间以及来自心脏病学、血液学、内分泌学、肺病学和其他专科的协调建议。本报告强调了EDS妊娠麻醉护理的复杂性，并强调需要根据特定的EDS亚型和个体患者情况调整管理措施。
