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超越肺结核后遗症:发现一名成人的常见变异型免疫缺陷

Beyond Post-tuberculosis Sequelae: Uncovering Common Variable Immunodeficiency in an Adult.

作者信息

Asaithambi Inbarasan, Thangaswamy Dhanasekar

机构信息

Pulmonology, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.

出版信息

Cureus. 2025 Aug 7;17(8):e89559. doi: 10.7759/cureus.89559. eCollection 2025 Aug.

Abstract

Common variable immunodeficiency (CVID) is a rare immunodeficiency syndrome presenting with wide manifestations and leading to a delayed diagnosis. A 40-year-old male, a case of old treated tuberculosis, presented with a productive cough and hemoptysis. He had a history of recurrent respiratory symptoms previously attributed to post-tuberculosis sequelae with bilateral bronchiectasis, which can also occur as a manifestation of underlying common variable immunodeficiency (CVID). After a detailed evaluation, serum immunoglobulin levels were markedly reduced, confirming CVID. The patient was started on intravenous immunoglobulin (IVIG) therapy every month. After a six-month follow-up, the patient was symptomatically better and had reduced hospitalizations.

摘要

普通可变型免疫缺陷(CVID)是一种罕见的免疫缺陷综合征,临床表现广泛,常导致诊断延迟。一名40岁男性,曾患陈旧性肺结核,出现咳痰和咯血症状。他既往有反复呼吸道症状的病史,之前归因于双侧支气管扩张的肺结核后遗症,而这也可能是潜在的普通可变型免疫缺陷(CVID)的一种表现。经过详细评估,血清免疫球蛋白水平显著降低,确诊为CVID。该患者开始每月接受静脉注射免疫球蛋白(IVIG)治疗。经过六个月的随访,患者症状明显改善,住院次数减少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f016/12413896/a75507d369bd/cureus-0017-00000089559-i01.jpg

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