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超声引导下乳腺病变标记物放置在精确局部定位、手术切除、新辅助化疗反应及化疗后随访中的作用

Role of Ultrasound-Guided Marker Placement in Breast Lesion for Precise Localization, Surgical Resection, Neoadjuvant Chemotherapy Response, and Post-Chemotherapy Follow-Up.

作者信息

Shaukat Suneela, Haroon Javeria, Afzal Faiza, Mazhar Sobia, Shaukat Zara, Ghaffar Zonia, Masood Mah Jabeen

机构信息

Department of Diagnostic Radiology, King Edward Medical University, Lahore, PAK.

Department of Diagnostic Radiology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.

出版信息

Cureus. 2025 Aug 5;17(8):e89402. doi: 10.7759/cureus.89402. eCollection 2025 Aug.

DOI:10.7759/cureus.89402
PMID:40918836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12409750/
Abstract

Objective To evaluate the effectiveness of ultrasound-guided marker placement in the precise localization of breast lesions, facilitate accurate surgical resection, and monitor tumor response during and after neoadjuvant chemotherapy. Materials and methods From January 2022 to December 2022, 70 female patients with breast carcinoma underwent a trial of metallic marker insertion into the tumor. The markers were made by cutting 5CC disposable syringe needles having a total length of 5 mm. These markers were inserted using a 16 G LP needle having a length of 10 cm. Results Among 70 female breast cancer patients (mean age 47.9 ± 8.0 years), ultrasound-guided metallic markers enabled precise tumor localization before, during, and after neoadjuvant chemotherapy. In 45 patients receiving chemotherapy, tumor size significantly decreased from 3.66 ± 0.69 cm to 0.61 ± 0.21 cm (p < 0.00001). Marker-guided surgery achieved complete tumor excision with negative margins. Intraoperative imaging and postoperative histopathology confirmed accurate localization and successful resection. Conclusion Ultrasound-guided marker placement enables precise tumor localization after neoadjuvant chemotherapy, improving surgical accuracy and breast cancer treatment outcomes.

摘要

目的 评估超声引导下放置标记物在乳腺病变精确定位中的有效性，促进准确的手术切除，并监测新辅助化疗期间及之后的肿瘤反应。材料与方法 2022年1月至2022年12月，70例女性乳腺癌患者接受了在肿瘤内插入金属标记物的试验。标记物由切割总长度为5毫米的5CC一次性注射器针头制成。使用长度为10厘米的16G LP针插入这些标记物。结果 在70例女性乳腺癌患者（平均年龄47.9±8.0岁）中，超声引导下的金属标记物能够在新辅助化疗前、化疗期间及化疗后实现肿瘤的精确定位。在45例接受化疗的患者中，肿瘤大小从3.66±0.69厘米显著减小至0.61±0.21厘米（p<0.00001）。标记物引导的手术实现了肿瘤的完整切除且切缘阴性。术中成像和术后组织病理学证实了定位准确且切除成功。结论 超声引导下放置标记物能够在新辅助化疗后实现肿瘤的精确定位，提高手术准确性和乳腺癌治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9463/12409750/fed34b3e7c66/cureus-0017-00000089402-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9463/12409750/efa60dce7452/cureus-0017-00000089402-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9463/12409750/8bbdc5f9492f/cureus-0017-00000089402-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9463/12409750/8ca7a5193d98/cureus-0017-00000089402-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9463/12409750/6e1f4efc91b3/cureus-0017-00000089402-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9463/12409750/3dfcd925552f/cureus-0017-00000089402-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9463/12409750/1c405ead6e2f/cureus-0017-00000089402-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9463/12409750/fed34b3e7c66/cureus-0017-00000089402-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9463/12409750/efa60dce7452/cureus-0017-00000089402-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9463/12409750/8bbdc5f9492f/cureus-0017-00000089402-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9463/12409750/8ca7a5193d98/cureus-0017-00000089402-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9463/12409750/6e1f4efc91b3/cureus-0017-00000089402-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9463/12409750/3dfcd925552f/cureus-0017-00000089402-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9463/12409750/1c405ead6e2f/cureus-0017-00000089402-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9463/12409750/fed34b3e7c66/cureus-0017-00000089402-i07.jpg

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Advantages and Challenges of Using Breast Biopsy Markers.使用乳腺活检标志物的优势与挑战。
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