Lopes Gonçalo T, Bem Bernardo, Mendonça Diogo, Oliveira Marcos, Samouco Gonçalo, Reis Madalena, Ribeiro Joana, Ferreira Luís
Pulmonology, Unidade Local de Saúde (ULS) da Guarda, Guarda, PRT.
Cureus. 2025 Aug 5;17(8):e89394. doi: 10.7759/cureus.89394. eCollection 2025 Aug.
Pulmonary atypical adenomatous hyperplasia (AAH) is a recognized precursor lesion to pulmonary adenocarcinoma (ADC). We present the case of a 79-year-old ex-smoker in whom transthoracic needle biopsy revealed histological features suggestive of lung ADC. However, surgical resection of the lesion later demonstrated only AAH. This discrepancy likely reflects sampling variability or partial lesion regression, emphasizing the diagnostic challenges posed by small pulmonary nodules. The case highlights the importance of integrating histopathological, radiological, and clinical data, and underscores the critical role of multidisciplinary decision-making in managing preinvasive pulmonary lesions.
肺非典型腺瘤样增生（AAH）是一种公认的肺腺癌（ADC）前驱病变。我们报告一例79岁的既往吸烟者，经胸针吸活检显示出提示肺ADC的组织学特征。然而，病变的手术切除后来仅显示为AAH。这种差异可能反映了取样变异性或部分病变消退，凸显了小肺结节带来的诊断挑战。该病例强调了整合组织病理学、放射学和临床数据的重要性，并强调了多学科决策在处理浸润前肺部病变中的关键作用。
