Lutke Schipholt Ivo J, Scholten-Peeters Gwendolyne G M, Koop Meghan A, Coppieters Michel W, Boellaard Ronald, van de Giessen Elsmarieke, Ter Meulen Bastiaan C, Coenen Marieke, Vleggeert-Lankamp Carmen, Depaauw Paul R, van Berckel Bart N M, Lammerstma Adriaan A, Yaqub Maqsood
Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences - Program Musculoskeletal Health, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Laboratory Medical Immunology, Department of Clinical Chemistry, Amsterdam University Medical Centre, Location VUmc, Amsterdam, Netherlands.
Front Nucl Med. 2025 Aug 21;5:1569991. doi: 10.3389/fnume.2025.1569991. eCollection 2025.
Animal models of nerve compression have revealed neuroinflammation not only at the entrapment site, but also remotely at the spinal cord. However, there is limited information on the presence of neuroinflammation in human compression neuropathies. The objectives of this study were to: (1) assess which tracer kinetic model most optimally quantified [C]DPA713 uptake in the spinal cord and neuroforamina in patients with painful cervical radiculopathy, (2) evaluate the performance of linearized methods (e.g., Logan) and simplified (e.g., standardized uptake value - SUV) methods, and (3) assess the test-retest reliability of these methods. Microglia activation associated with neuroinflammation was quantified using positron emission tomography (PET) with the radiotracer [C]DPA713, targeting the 18 kDa translocator protein (TSPO). The Akaike information criterion, visual inspection of the fits and number of outliers were used to select the optimal kinetic model. As unaffected tissue, the spinal cord and neuroforamina three cervical levels above the affected target tissue was used.
The single tissue (1T2k) compartment model was the preferred model to describe [C]DPA713 kinetics at the spinal cord and neuroforamina. Higher levels of 1T2k were observed in the affected neuroforamina and spinal cord compared with corresponding unaffected tissues. Logan (≥0.73) showed high correlation with 1T2k at both locations. Of the simplified methods, neuroforamina and spinal cord SUV normalized for the metabolite corrected plasma (TBR-PP) exhibited high correlations with 1T2k (r ≥ 0.84). Test-retest reliability varied between fair to excellent.
These results indicate that a 1T2k model with metabolite corrected image derived input function can be used to describe the kinetics of [C]DPA713 in the spinal cord and neuroforamina in humans. 1T2k or Logan can be used as binding metric, while TBR-PP is the recommended choice among simplified models.
神经压迫动物模型显示，神经炎症不仅出现在卡压部位，在脊髓处也有出现，且位置较远。然而，关于人类压迫性神经病变中神经炎症的存在情况，相关信息有限。本研究的目的是：（1）评估哪种示踪剂动力学模型能最优化地量化疼痛性颈神经根病患者脊髓和神经孔中[C]DPA713的摄取情况；（2）评估线性化方法（如洛根法）和简化方法（如标准化摄取值-SUV）的性能；（3）评估这些方法的重测可靠性。使用放射性示踪剂[C]DPA713进行正电子发射断层扫描（PET），以量化与神经炎症相关的小胶质细胞激活情况，该示踪剂靶向18 kDa转位蛋白（TSPO）。采用赤池信息准则、拟合的视觉检查和异常值数量来选择最佳动力学模型。将受影响目标组织上方三个颈椎水平的脊髓和神经孔作为未受影响组织。
单组织（1T2k）隔室模型是描述脊髓和神经孔中[C]DPA713动力学的首选模型。与相应的未受影响组织相比，在受影响的神经孔和脊髓中观察到更高水平的1T2k。洛根法（≥0.73）在两个位置与1T2k均显示出高度相关性。在简化方法中，经代谢物校正血浆标准化的神经孔和脊髓SUV（TBR-PP）与1T2k表现出高度相关性（r≥0.84）。重测可靠性在一般到优秀之间变化。
这些结果表明，具有经代谢物校正的图像衍生输入函数的1T2k模型可用于描述人类脊髓和神经孔中[C]DPA713的动力学。1T2k或洛根法可作为结合指标，而TBR-PP是简化模型中的推荐选择。
