Pan Kaisu, Lu Danxia, Wu Weixuan, Luo Ping, Liao Liuwei, Liang Dong, Liao Wanqing, Cao Cunwei, Zheng Dongyan
Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People's Republic of China.
Laboratory Department of Mashan County People's Hospital, Nanning, 530600, People's Republic of China.
Infect Drug Resist. 2025 Sep 2;18:4615-4620. doi: 10.2147/IDR.S514483. eCollection 2025.
Cutaneous cryptococcosis is rarely caused by , especially in immunocompetent individuals. We report a unique case of perioral cutaneous infection in a 37-year-old male with scattered erythematous, pruritic, and scaly lesions lasting over a month. Initial clinical presentation mimicked common dermatological conditions, leading to potential misdiagnosis. Diagnosis was confirmed through fungal culture, fluorescence microscopy, MALDI-TOF mass spectrometry and molecular identification. The patient was successfully treated with oral itraconazole and topical fluconazole cream for six weeks. This case underscores the importance of considering rare fungal infections in atypical presentations to prevent misdiagnosis and delays in treatment.
皮肤隐球菌病很少由 引起，尤其是在免疫功能正常的个体中。我们报告了一例独特的口周皮肤感染病例，患者为一名37岁男性，有散在的红斑、瘙痒和鳞屑性皮损，持续一个多月。最初的临床表现类似于常见的皮肤病，导致可能的误诊。通过真菌培养、荧光显微镜检查、基质辅助激光解吸电离飞行时间质谱分析和分子鉴定确诊。患者口服伊曲康唑和外用氟康唑乳膏成功治疗六周。该病例强调了在非典型表现中考虑罕见真菌感染以防止误诊和治疗延误的重要性。
