2000年至2020年美国25岁以下人群癌症的发病率和5年相对生存率：一项监测、流行病学和最终结果（SEER）回顾性研究及生育力保存考量
The Incidence and 5-Years Relative Survival Rate of Cancer Among People Younger Than 25 Years in the US, 2000 to 2020: A SEER-Retrospective Study and Fertility Preservation Considerations.
作者信息
Xiao Chengqi, Ji Min, Lai Dongmei
机构信息
The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China.
出版信息
Sage Open Pediatr. 2025 Sep 2;12:30502225251370801. doi: 10.1177/30502225251370801. eCollection 2025 Jan-Dec.
OBJECTIVE
To report the incidence and survival patterns for children, adolescents, and young adults (CAYA) cancer survivors over the past 20 years.
METHODS
CAYA (under 25 years old) cancer survivors from 17 Surveillance, Epidemiology, and End Results (SEER) registries from 2000 to 2020 were analyzed. A joinpoint regression model was used to analyze the incidence and 5-year survival rate.
RESULTS
The overall age-standardized cancer incidence (ASIR) of CAYA cancer was 19.26 per 100 000 in 2000 and 21.47 per 100 000 in 2020 in SEER17. The incidence rate of CAYA cancer increased over time. The most common cancer types were leukemia, lymphoma, brain and other nervous system, endocrine system, and male genital system cancer, accounting for over 60% of CAYA cancer cases. The 5-year relative survival rate of CAYA increased from 80.40% in 2000 to 87.80% in 2015.
CONCLUSIONS
There were more CAYA cancer survivors at risk of long-term sequelae.
目的
报告过去20年儿童、青少年和青年（CAYA）癌症幸存者的发病率和生存模式。
方法
分析了2000年至2020年来自17个监测、流行病学和最终结果（SEER）登记处的CAYA（25岁以下）癌症幸存者。采用连接点回归模型分析发病率和5年生存率。
结果
在SEER17中，2000年CAYA癌症的总体年龄标准化发病率（ASIR）为每10万人19.26例，2020年为每10万人21.47例。CAYA癌症的发病率随时间增加。最常见的癌症类型是白血病、淋巴瘤、脑和其他神经系统、内分泌系统以及男性生殖系统癌症，占CAYA癌症病例的60%以上。CAYA的5年相对生存率从2000年的80.40%提高到2015年的87.80%。
结论
有更多的CAYA癌症幸存者面临长期后遗症的风险。
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