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采用回波不对称与最小二乘估计的迭代水脂分离法(IDEAL-IQ)评估老年骨质疏松症患者早期骨量变化

Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL-IQ) for evaluation of early bone mass changes in ageing osteoporosis patients.

作者信息

Yang Yonggui, Chen Fang, Wu Xiufen, Xu Xinyu, Wu Pu-Yeh

机构信息

Department of Radiology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, 361021, China.

GE Healthcare, Beijing, 100176, China.

出版信息

Magn Reson Lett. 2024 Oct 25;5(2):200157. doi: 10.1016/j.mrl.2024.200157. eCollection 2025 May.

Abstract

This study explored the application value of iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL-IQ) technology in the early diagnosis of ageing osteoporosis (OP). 172 participants were enrolled and underwent magnetic resonance imaging (MRI) examinations on a 3.0T scanner. 100 cases were included in the normal group (50 males and 50 females; mean age: 45 years; age range: 20-84 years). 33 cases were included in the osteopenia group (17 males and 16 females; mean age: 55 years; age range: 43-83 years). 39 cases were included in the OP group (19 males and 20 females; mean age: 58 years; age range: 48-82 years). Conventional TWI and TWI were first obtained, followed by 3D-IDEAL-IQ-acquisition. Fat fraction () and apparent transverse relaxation rate ( ) results were automatically calculated from IDEAL-IQ-images on the console. Based on TW and TW-images, 300 ROIs for each participant were manually delineated in L-L vertebral bodies of five middle slices. In each age group of all normal subjects, each parameter was significantly correlated with gender. In male participants from the normal, osteopenia, and OP groups, statistical analysis revealed values of 11319.292 and 180.130 for comparisons involving and values, respectively (all < 0.0001). The sensitivity and specificity of values were 0.906 and 0.950, 0.994 and 0.997, 0.865 and 0.820, respectively. For , they were 0.665 and 0.616, 0.563 and 0.519, 0.571 and 0.368, respectively. In female participants from the normal, osteopenia, and OP-groups, statistical analysis revealed values of 12461.658 and 548.274 for comparisons involving and values, respectively (all < 0.0001). The sensitivity and specificity of values were 0.985 and 0.991, 0.996 and 0.996, 0.581 and 0.678, respectively. For , they were 0.698 and 0.730, 0.603 and 0.665, 0.622 and 0.525, respectively. Significant differences were indicated in the quantitative values among the three groups. value had good performance, while value had poor performance in discriminating osteopenia and OP-groups. Overall, the IDEAL-IQ technique offers specific reference indices that enable noninvasive and quantitative assessment of lumbar vertebrae bone metabolism, thereby providing diagnostic information for OP.

摘要

本研究探讨了采用回波不对称最小二乘估计迭代水脂分离(IDEAL - IQ)技术在老年骨质疏松症(OP)早期诊断中的应用价值。纳入172名参与者,在3.0T扫描仪上进行磁共振成像(MRI)检查。正常组100例(男性50例,女性50例;平均年龄:45岁;年龄范围:20 - 84岁)。骨量减少组33例(男性17例,女性16例;平均年龄:55岁;年龄范围:43 - 83岁)。OP组39例(男性19例,女性20例;平均年龄:58岁;年龄范围:48 - 82岁)。首先获取常规TWI和TWI,随后进行三维IDEAL - IQ采集。在控制台通过IDEAL - IQ图像自动计算脂肪分数()和表观横向弛豫率()结果。基于TWI和TWI图像,在五个中间层面的L - L椎体中为每位参与者手动勾画300个感兴趣区(ROI)。在所有正常受试者的各年龄组中,各参数与性别均显著相关。在正常组、骨量减少组和OP组的男性参与者中,统计分析显示,在涉及和值的比较中,值分别为11319.292和180.130(均<0.0001)。值的敏感性和特异性分别为0.906和0.950、0.994和0.997、0.865和0.820。对于,其敏感性和特异性分别为0.665和0.616、0.563和0.519、0.571和0.368。在正常组、骨量减少组和OP组的女性参与者中,统计分析显示,在涉及和值的比较中,值分别为12461.658和548.274(均<0.0001)。值的敏感性和特异性分别为0.985和0.991、0.996和0.996、0.581和0.678。对于,其敏感性和特异性分别为0.698和0.730、0.603和0.665、0.622和0.525。三组间定量值存在显著差异。值表现良好,而在区分骨量减少组和OP组时表现不佳。总体而言,IDEAL - IQ技术提供了特定的参考指标,能够对腰椎骨代谢进行无创定量评估,从而为OP提供诊断信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe88/12406565/e69c7e1e4a07/ga1.jpg

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