Xu Qiaoqiao, Tao Chengzhe, Dai Sijia, Lu Zhixi, Aschner Michael, Long Guangfeng, Li Shaojun, Xu Cheng
State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
J Alzheimers Dis Rep. 2025 Sep 4;9:25424823251370717. doi: 10.1177/25424823251370717. eCollection 2025 Jan-Dec.
Adverse reproductive outcomes (AROs) in women can lead to the occurrence of a variety of diseases later in life. However, research on AROs and dementia risk in women has not been reported.
This study explored the effects of miscarriage and stillbirth on future dementia risk in women.
The Cox proportional hazards model was used to clarify the association between miscarriage, stillbirth, and dementia risk. In this cohort, only women with a history of miscarriage and stillbirth were selected. A genetic risk score for dementia was constructed, and the combined effect of miscarriage, stillbirth, and the genetic risk score for dementia on the future risk of incident dementia was determined.
For each increase in the number of miscarriages and stillbirths, the risk of dementia increased by 5% and 22%, respectively. Compared to women who had a low genetic risk score, no miscarriages and at least one live-born infant, women with more than 3 miscarriages and a high genetic risk score had a significantly increased risk of dementia.
Our results indicate that miscarriage and stillbirth are associated with an increased risk of dementia, especially in women with a high genetic risk score.
女性的不良生殖结局（AROs）可能导致日后多种疾病的发生。然而，关于女性AROs与痴呆风险的研究尚未见报道。
本研究探讨流产和死产对女性未来痴呆风险的影响。
采用Cox比例风险模型阐明流产、死产与痴呆风险之间的关联。在该队列中，仅选择有流产和死产史的女性。构建痴呆的遗传风险评分，并确定流产、死产和痴呆遗传风险评分对未来痴呆发病风险的综合影响。
流产和死产次数每增加一次，痴呆风险分别增加5%和22%。与遗传风险评分低、无流产且至少有一个活产婴儿的女性相比，流产3次以上且遗传风险评分高的女性患痴呆的风险显著增加。
我们的结果表明，流产和死产与痴呆风险增加有关，尤其是在遗传风险评分高的女性中。
