Gao Feng, Deng Chunhua, Luo Peng
Department of Urology and Andrology, The First Affiliated Hospital, Sun Yat-sen University, 510080 Guangzhou, Guangdong, China.
Reproductive Medicine Center, The Key Laboratory for Reproductive Medicine of Guangdong Province, The First Affiliated Hospital, Sun Yat-sen University, 510080 Guangzhou, Guangdong, China.
Int J Vitam Nutr Res. 2025 Jul 30;95(4):26559. doi: 10.31083/IJVNR26559.
Obesity, a prevalent global health issue, is associated with testosterone deficiency (TD). A body shape index (ABSI) provides a more precise assessment of obesity and visceral fat, but its relationship with testosterone remains unclear. This study aimed to explore the association between ABSI and testosterone levels leading to TD.
Data from 5256 adult males participating in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2016 were collected to analyze of the association between ABSI and TD. The data underwent analysis using multivariate linear regression, logistic regression, restricted cubic spline (RCS) analysis, subgroup analysis, and interaction testing. The predictive ability of ABSI based on weight, height, and waist circumference, as well as body mass index (BMI) based on weight and height, alongside a multiplicative combination of both metrics, BMI × ABSI, and optimal proportional combination O for assessing TD risk, was valuated using receiver operating characteristic (ROC) curves.
Following adjustment for all confounding factors, ABSI exhibited a negative linear correlation with testosterone (β = -6.99, 95% confidence interval (CI): -8.25 to -5.73; < 0.001) and a positive association with TD risk (odds ratio (OR) = 1.06, 95% CI: 1.04-1.08; < 0.001). Notably, these associations remained consistent in the subgroup analysis. Additionally, age and hypertension demonstrated significant interactions between ABSI and TD ( < 0.05). Moreover, combining metrics, such as BMI × ABSI and O, proved to be more reliable predictors of TD compared to BMI or ABSI alone.
This study identified a negative linear correlation between ABSI and total testosterone levels in adult American males, as well as a positive linear correlation with TD prevalence. ABSI represents a valuable addition to BMI for assessing obesity and the association between obesity and TD.
肥胖是一个普遍存在的全球健康问题，与睾酮缺乏（TD）有关。体型指数（ABSI）能更精确地评估肥胖和内脏脂肪，但它与睾酮的关系仍不明确。本研究旨在探讨ABSI与导致TD的睾酮水平之间的关联。
收集了2011年至2016年参与美国国家健康与营养检查调查（NHANES）的5256名成年男性的数据，以分析ABSI与TD之间的关联。数据采用多元线性回归、逻辑回归、限制性立方样条（RCS）分析、亚组分析和交互作用检验进行分析。基于体重、身高和腰围的ABSI以及基于体重和身高的体重指数（BMI），以及这两个指标的乘积组合BMI×ABSI和用于评估TD风险的最佳比例组合O的预测能力，使用受试者工作特征（ROC）曲线进行评估。
在对所有混杂因素进行调整后，ABSI与睾酮呈负线性相关（β = -6.99，95%置信区间（CI）：-8.25至-5.73；P < 0.001），与TD风险呈正相关（优势比（OR） = 1.06，95% CI：1.04 - 1.08；P < 0.001）。值得注意的是，这些关联在亚组分析中仍然一致。此外，年龄和高血压在ABSI与TD之间表现出显著的交互作用（P < 0.05）。而且，与单独的BMI或ABSI相比，结合BMI×ABSI和O等指标被证明是TD更可靠的预测指标。
本研究发现美国成年男性的ABSI与总睾酮水平之间存在负线性相关，与TD患病率呈正线性相关。ABSI是BMI在评估肥胖以及肥胖与TD之间关联方面的一个有价值的补充。
