胺碘酮可降低人体血浆华法林清除率。
Amiodarone reduces plasma warfarin clearance in man.
作者信息
Watt A H, Stephens M R, Buss D C, Routledge P A
出版信息
Br J Clin Pharmacol. 1985 Dec;20(6):707-9. doi: 10.1111/j.1365-2125.1985.tb05135.x.
Abstract
Amiodarone is an effective antiarrhythmic agent whose use is associated with several drug interactions one of which is potentiation of the action of warfarin. The mechanism of this interaction has hitherto been unclear. We examined possible mechanisms in eight patients. Total plasma warfarin clearance was found to be reduced by amiodarone. No change was detected in the binding of warfarin to plasma proteins. No relationship was found between plasma amiodarone concentrations and the change in warfarin clearance.
摘要
胺碘酮是一种有效的抗心律失常药物，其使用与多种药物相互作用有关，其中之一是增强华法林的作用。迄今为止，这种相互作用的机制尚不清楚。我们在8名患者中研究了可能的机制。发现胺碘酮可降低华法林的总血浆清除率。未检测到华法林与血浆蛋白结合的变化。未发现血浆胺碘酮浓度与华法林清除率变化之间存在关联。
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本文引用的文献
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