Nguyen Tien C, Zyczynski Halina, Ackenbom Mary F, Zuo Stephanie W
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Int Urogynecol J. 2025 Sep 8. doi: 10.1007/s00192-025-06277-w.
Aging may place patients at greater risk for adverse perioperative outcomes. We hypothesized that women undergoing minimally invasive (MIS) sacrocolpopexy aged ≥ 70 years are more likely to experience adverse events (AE) within 8 weeks of surgery.
We performed a secondary analysis of a retrospective study on perioperative adverse events in women ≥ 61 years old undergoing prolapse surgery at a single academic center from January 2016 to May 2023. Only women undergoing MIS sacrocolpopexy were included. The primary outcome was a composite 8-week AE outcome. Secondary outcomes included prolapse recurrence and mesh complication. Variables were compared between the groups using t-test (or Mann-Whitney U) and chi-square (or Fisher's exact) analyses. Multivariable logistic regression was performed, controlling for variables with p < 0.05 on univariate analysis.
Of the 709 women who underwent MIS sacrocolpopexy, 29.9% (n = 212) were aged ≥ 70 years. Age ≥ 70 was not significantly associated with 8-week perioperative AEs, nor was it associated with prolapse recurrence or mesh complication. The composite AE outcome was not associated with age ≥ 70 on multivariable analysis, controlling for CCI score, robotic approach, and concomitant hysterectomy (adjusted odds ratio (aOR) 0.64, 95% confidence interval (CI) [0.38-1.10]). Women aged ≥ 70 years had a 73% lesser adjusted odds of surgical site infections on multivariable analysis (95% CI [0.08-0.93]).
Age ≥ 70 years is not associated with perioperative AEs, prolapse recurrence, or mesh complication. These findings highlight the safety profile of this surgical approach in older women, an important consideration for urogynecologic surgeons caring for an aging population.
衰老可能使患者围手术期出现不良结局的风险更高。我们假设,年龄≥70岁的女性接受微创骶骨阴道固定术时,在术后8周内更有可能发生不良事件(AE)。
我们对2016年1月至2023年5月在单一学术中心接受脱垂手术的年龄≥61岁女性围手术期不良事件的回顾性研究进行了二次分析。仅纳入接受微创骶骨阴道固定术的女性。主要结局是8周综合不良事件结局。次要结局包括脱垂复发和网片并发症。使用t检验(或曼-惠特尼U检验)和卡方检验(或费舍尔精确检验)对组间变量进行比较。进行多变量逻辑回归分析,对单变量分析中p<0.05的变量进行控制。
在709例接受微创骶骨阴道固定术的女性中,29.9%(n = 212)年龄≥70岁。年龄≥70岁与术后8周围手术期不良事件无显著相关性,也与脱垂复发或网片并发症无关。在多变量分析中,控制了CCI评分、机器人手术方式和同期子宫切除术后,综合不良事件结局与年龄≥70岁无关(调整优势比(aOR)为0.64,95%置信区间(CI)[0.38 - 1.10])。在多变量分析中,年龄≥70岁的女性手术部位感染的调整优势比降低了73%(95% CI [0.08 - 0.93])。
年龄≥70岁与围手术期不良事件、脱垂复发或网片并发症无关。这些发现突出了这种手术方法在老年女性中的安全性,这是关爱老年人群的妇科泌尿外科医生的一个重要考虑因素。