Tian Yuan, Tao Kang, Zhou Hongyan, Li Shifei, Chen Xiaoqiang, Zhang Mingwang, Zhai Zhifang
Department of Dermatology, the First Affiliated Hospital, Army Medical University, No. 29 Gaotanyan Street, Shapingba District, Chongqing, China.
Department of Dermatology, General Hospital of Central Theater Command, Wuhan, China.
Clin Rheumatol. 2025 Sep 8. doi: 10.1007/s10067-025-07674-8.
Plasmacytoid dendritic cells (pDCs) are a specialized subset of dendritic cells known for their ability to produce type I interferon (IFN I), contributing to antiviral defense and the pathogenesis of autoimmune diseases like systemic lupus erythematosus (SLE). In SLE patients, pDCs are excessively activated, leading to overproduction of IFN-α, which plays a critical role in disease progression. However, no bibliometric analysis has been conducted on the relationship between pDCs and SLE. This study aims to map the knowledge structure and trends in research on pDCs in SLE through bibliometric analysis.
We analyzed publications related to pDCs in SLE from 2004 to 2023 using the Web of Science Core Collection. Data were analyzed and visualized with VOSviewers, CiteSpace, and the R package bibliometrix, offering a comprehensive view of the research landscape.
The analysis included 1086 articles from 57 countries, with the USA leading in publication volume. Major contributing institutions include Uppsala University, University of Michigan, and Baylor Institute for Immunology Research. Among the 565 authors, Ronnblom Lars was the most prolific, while Elkon Keith B ranked highest in terms of network centrality. Key research themes focus on pDC mechanisms in SLE development and emerging therapeutic strategies. Trending topics include "anifrolumab," "mortality," and "population."
This bibliometric study provides a thorough overview of research trends on pDCs in SLE, identifying recent advances and key areas of interest, offering valuable insight for future research directions.
• pDCs play a crucial role in systemic lupus erythematosus (SLE) through the overproduction of type I interferon (IFN-α). • This is the first bibliometric analysis mapping the research landscape of pDCs in SLE from 2004 to 2023. • Emerging research focuses on therapeutic strategies, including trending topics like "anifrolumab" and "mortality" in SLE. • This study offers valuable insights into key research themes and trends, guiding future investigations on pDCs in SLE.
浆细胞样树突状细胞（pDC）是树突状细胞的一个特殊亚群，以其产生I型干扰素（IFN I）的能力而闻名，有助于抗病毒防御以及自身免疫性疾病（如系统性红斑狼疮，SLE）的发病机制。在SLE患者中，pDC被过度激活，导致IFN-α过度产生，这在疾病进展中起关键作用。然而，尚未对pDC与SLE之间的关系进行文献计量分析。本研究旨在通过文献计量分析描绘SLE中pDC研究的知识结构和趋势。
我们使用Web of Science核心合集分析了2004年至2023年期间与SLE中pDC相关的出版物。使用VOSviewer、CiteSpace和R包bibliometrix对数据进行分析和可视化，全面呈现研究概况。
分析包括来自57个国家的1086篇文章，美国的发文量领先。主要贡献机构包括乌普萨拉大学、密歇根大学和贝勒免疫研究所。在565位作者中，Ronnblom Lars的发文量最多，而Elkon Keith B在网络中心性方面排名最高。关键研究主题集中在SLE发病机制中的pDC机制和新兴治疗策略。热门话题包括“阿尼鲁单抗”、“死亡率”和“人群”。
这项文献计量研究全面概述了SLE中pDC的研究趋势，确定了近期进展和关键关注领域，为未来研究方向提供了有价值的见解。
• pDC通过过度产生I型干扰素（IFN-α）在系统性红斑狼疮（SLE）中起关键作用。• 这是首次对2004年至2023年SLE中pDC的研究概况进行文献计量分析。• 新兴研究集中在治疗策略，包括SLE中的热门话题如“阿尼鲁单抗”和“死亡率”。• 本研究为关键研究主题和趋势提供了有价值的见解，指导未来对SLE中pDC的研究。
