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印度通过规模性强化食用油和牛奶来减少维生素A和维生素D缺乏症的成本效益分析。

Cost-effectiveness of oil and milk fortification by scale for reducing Vitamin A and Vitamin D deficiency in India.

作者信息

Kumar Abhishek, Ahluwalia Komal, Edathil Anirudhan P, Sankar Rajan, Arlappa Nimmathota, Nair Sirimavo, Duggal Mona, Joe William

机构信息

Department of Economics, School of Liberal Education, FLAME University, Lavale, Maharashtra, India.

Institute of Economic Growth, Delhi University Enclave (North Campus), Delhi, India.

出版信息

PLoS One. 2025 Sep 8;20(9):e0331790. doi: 10.1371/journal.pone.0331790. eCollection 2025.

Abstract

BACKGROUND

Although broad-scale data might suggest low prevalence, millions of children in India still suffer from Vitamin A and Vitamin D deficiencies despite India's existing guidelines for Vitamin A deficiency. To address the issue, the Government of India has recommended fortification of oil and milk to improve Vitamin A and Vitamin D consumption. However, there is limited information on the health benefits and cost-effectiveness of fortifying oil and milk at scale.

OBJECTIVE

To estimate the health benefits and cost-effectiveness of supplementation programme and fortification of milk and oil among children under 5 years, pregnant women, women in the reproductive age group, and the elderly.

DATA AND METHODS

To measure the health benefits associated with supplementation and fortification of oil and milk, the number of DALYs that are currently lost due to Vitamin A and Vitamin D deficiencies were estimated. For Vitamin A related mortality, a reduction of 4%, 12% and 23% were assumed while the assumptions for estimating morbidity benefits were derived from Global Burden of Disease. For the costing exercise, we considered the following two scenarios: (1) high-dose vitamin A supplementation for children and pregnant women; (2) industrial fortification of oil for children, pregnant women, women in the reproductive age group, and the elderly.

RESULTS

Overall, intervention related to Vitamin A could avert 1,119,044 Years of Life Lost (YLLs) at a 23% reduction, 194,616 YLLs at 4%, and 583,849 YLLs at 12% and 28,534 YLDs. Intervention related to Vitamin D could avert 99,219 YLDs. The total cost for supplying supplements to approximately 109,965 thousand children and 26,920 thousand pregnant women is around 26 million USD. The cost to fortify is 7.6 million USD for oil and 9.8 million USD for milk fortification for children and women. The overall cost effectiveness ratio of the fortification programme is 150.

CONCLUSION

Fortification could emerge as a potentially superior long-term solution, considering the widespread consumption of oil and milk, offering a broader reach to the population.

摘要

背景

尽管大规模数据可能显示患病率较低,但尽管印度已有维生素A缺乏症的相关指南,仍有数百万印度儿童患有维生素A和维生素D缺乏症。为解决这一问题,印度政府建议对食用油和牛奶进行强化,以提高维生素A和维生素D的摄入量。然而,关于大规模强化食用油和牛奶对健康的益处及成本效益的信息有限。

目的

评估补充计划以及对5岁以下儿童、孕妇、育龄妇女和老年人进行牛奶及食用油强化的健康益处和成本效益。

数据与方法

为衡量与食用油和牛奶补充及强化相关的健康益处,估算了目前因维生素A和维生素D缺乏而损失的伤残调整生命年(DALY)数量。对于与维生素A相关的死亡率,假设降低4%、12%和23%,而估算发病益处的假设则源自全球疾病负担研究。在成本核算方面,我们考虑了以下两种情况:(1)为儿童和孕妇补充大剂量维生素A;(2)对儿童、孕妇、育龄妇女和老年人的食用油进行工业强化。

结果

总体而言,与维生素A相关的干预措施在降低23%的情况下可避免1,119,044生命年损失(YLL),在降低4%的情况下可避免194,616 YLL,在降低12%的情况下可避免583,849 YLL以及28,534伤残调整生命年(YLD)。与维生素D相关的干预措施可避免99,219 YLD。为大约1.09965亿儿童和269.2万孕妇提供补充剂的总成本约为2600万美元。食用油强化成本为760万美元,儿童和妇女的牛奶强化成本为980万美元。强化计划的总体成本效益比为150。

结论

考虑到食用油和牛奶的广泛消费,强化可能成为一种潜在的更优长期解决方案,能惠及更广泛的人群。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6e2/12416695/bcbeae2fad95/pone.0331790.g001.jpg

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